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Recombinant human IL-17F (HZ-1116) stimulates dose-dependent induction of alkaline phosphatase production in a HEK293 reporter cell line. Alkaline phosphatase production was assessed using pNPP as a chromogenic substrate. The EC50 was determined using a 4-parameter non-linear regression model. The EC50 value range is 4.5-22.5 ng/mL.
Animal-free Recombinant Human IL-17F is a homodimeric glycoprotein with an apparent molecular mass of 38 kDa. This cytokine is produced in a human cell expression system with serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, which contributes to stability in cell growth media and other applications. IL-17 is commonly associated with allergic responses. IL-17 induces the production of many other cytokines (such as IL-6, G-CSF, GM-CSF, IL-1beta, TGF beta, and TNF alpha), chemokines (including IL-8, GRO alpha, and MCP-1), and prostaglandins (e.g., PGE2) from many cell types (fibroblasts, endothelial cell, epithelial cells, keratinocytes, and macrophages). The release of cytokines causes many functions, such as airway remodeling, a characteristic of IL-17 responses.
IL-17F is a homodimeric glycoprotein with an apparent molecular mass of 38 kDa. IL-17 is commonly associated with allergic responses. IL-17 induces the production of many other cytokines such as TNF alpha, chemokines such as IL-8 and prostaglandins. The IL17-induced release of cytokines has many effects, including airway remodeling in asthma (PMID 24292568)