Validation Data Gallery
Technical Specifications
| GeneID | 7042 |
| Species | Human |
| Expression | HEK293 |
| Activity | 0.018-0.18 ng/mL |
| Specific Activity | minimally 2.00 x 107 IU/mg |
| Purity | >95% |
| Endotoxin | <1 EU/μg |
| Accession Number | P27090 |
| Molecular Mass | 13 kDa reduced, 23 kDa non-reduced, homodimer, non-glycosylated |
| Formulation | 50 mM NaOAc pH 3.7, See Certificate of Analysis for details |
| Species Reactivity | human,mouse |
Stability and Reconstitution
| Stability and Storage | Product Form | Temperature Conditions | Storage Time (From Date of Receipt) |
|---|---|---|---|
| Lyophilized | -20°C to -80°C | Until Expiry Date | |
| Lyophilized | Room Temperature | 2 weeks | |
| Reconstituted as per CofA | -20°C to -80°C | 6 months | |
| Reconstituted as per CofA | 4°C | 1 week | |
| Avoid repeated freeze-thaw cycles. | |||
| Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in sterile 20% ethanol + 50 mM NaOAc + 75 mM HOAc. Gently swirl or tap vial to mix. |
Background
Transforming growth factor beta-2 (TGFB2) belongs to the TGF-beta family. TGFB2 is a secreted protein known as a cytokine that plays a vital role during embryonic development (PMID 19289080). TGFB2 regulates cell proliferation, differentiation, adhesion, migration by transducing the signal through transmembrane receptors type I and type II (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins (PMID 18313409). Disruption of the TGFB/SMAD pathway has been implicated in many cancers types. TGFB2 has suppressive effects on interleukin-2 dependent T-cell growth (PMID 12064833). The TGFβ2 protein plays a role in the blood vessels formation, the regulation of muscle tissue and body fat development. TGFβ-2 is especially abundant in tissues related to the skeleton, where it helps regulate bone growth and form the extracellular matrix in the spaces between cells.
Synonyms
BSC 1 cell growth inhibitor, Cetermin, G TSF, Polyergin, TGF beta 2, TGF beta2, TGFB2
Publications
| Species | Title |
|---|---|
J Cell Mol Med FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity. | |
Biol Reprod Constitutive activation of transforming growth factor Beta receptor 1 in the mouse uterus impairs uterine morphology and function. | |
Invest Ophthalmol Vis Sci Aldose Reductase Mediates Transforming Growth Factor β2 (TGF-β2)-Induced Migration and Epithelial-To-Mesenchymal Transition of Lens-Derived Epithelial Cells. | |
Front Oncol Association of the TGFβ gene family with microenvironmental features of gastric cancer and prediction of response to immunotherapy | |
BMC Genomics Transcriptome exploration of ferroptosis-related genes in TGFβ- induced lens epithelial to mesenchymal transition during posterior capsular opacification development |