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TLR2 Monoclonal antibody, PBS Only (Capture)

TLR2 Monoclonal Antibody for WB, IHC, IF/ICC, Cytometric bead array, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

human

Applications

WB, IHC, IF/ICC, Cytometric bead array, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1C1D3

Cat no : 66645-1-PBS

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Synonyms

Toll-like receptor 2, Toll/interleukin-1 receptor-like protein 4, toll like receptor 2, TIL4, CD282



产品信息

66645-1-PBS targets TLR2 as part of a matched antibody pair:

MP50388-1: 66645-1-PBS capture and 66645-2-PBS detection (validated in Cytometric bead array)

MP50388-3: 66645-1-PBS capture and 66645-4-PBS detection (validated in Cytometric bead array)

Unconjugated mouse monoclonal antibody pair in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

Tested Applications WB, IHC, IF/ICC, Cytometric bead array, Indirect ELISA Application Description
Tested Reactivity human
Immunogen TLR2 fusion protein Ag25626 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name toll-like receptor 2
Synonyms Toll-like receptor 2, Toll/interleukin-1 receptor-like protein 4, toll like receptor 2, TIL4, CD282
Calculated Molecular Weight 784 aa, 90 kDa
Observed Molecular Weight 90-100 kDa
GenBank Accession NumberBC033756
Gene Symbol TLR2
Gene ID (NCBI) 7097
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDO60603
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLR receptors are type I integral transmembrane glycoproteins which play a fundamental role in pathogen recognition and activation of innate immunity. TLR2 is expressed by immune cells including monocytes/macrophages, polymorphonuclear leukocytes (PMLs) and dendritic cells, and is also expressed by some no-immune cells including endothelial and epithelial cells (PMID: 21428911; 22566960). TLR2 forms heterodimers with TLR1 and TLR6, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae related to infection with these pathogens (PMID: 22566960).