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740 Y-P acetate

740 Y-P acetate (740YPDGFR acetate) 是一个有效的且具有细胞渗透性的 PI3K 激活剂。740 Y-P acetate 倾向和含有 p85 的 N- 和 C- 末端 SH2 结构域的 GST 融合蛋白结合，但不能单独结合 GST。

CAS号

TQ0003L1

分子式

C143H226N43O41PS3

主要靶点

PI3K

仅限科研使用

Cat No : CM19943

Print datasheet

Synonyms

740 Y-P acetate(1236188-16-1 Free base)|PDGFR 740Y-P Acetate|740YPDGFR acetate

验证数据展示

  • CAS No.: TQ0003L1

    740 Y-P acetate
    CAS#: TQ0003L1

产品信息

740 Y-P acetate is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-terminal SH2 structural domains of p85, but not to GST alone.

CAS号 TQ0003L1
分子式 C143H226N43O41PS3
主要靶点 PI3K
主要通路 PI3K/Akt/mTOR信号通路
分子量 3330.79
纯度 ， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 740 Y-P acetate(1236188-16-1 Free base)|PDGFR 740Y-P Acetate|740YPDGFR acetate

靶点活性

PI3K:20 μM

体外活性

740 Y-P TFA (1 μg/mL) stimulates Mitosis at the lowest concentration tested. The peptide stimulates Mitosis in the presence and absence of serum (0.5%). In the former instance, The maximum reaction was observed at 50 μg/mL. 740Y-P stimulation of Mitosis is highly specific, rather than the general characteristics of cell-permeable SH2 domain binding peptides. [1] 740 Y-P TFA (50 μg/ml; 48 h) in the culture medium, the specific stimulation of Mitosis was superior to EGF or FGF in stimulating the entry of S phase, which showed that the percentage of S phase cells in C2 cells was 48.3%. In addition, LY294002 or wortmannin effectively inhibited the Mitosis response stimulated by the 740Y-P TFA peptide. [1] 740 Y-P TFA (30 μM; 24 h) significantly inhibited the levels of LC3-II/LC3-I in GO induced PC12 cells. [2]

溶解度

H2O:83.3 mg/mL (25 mM),DMSO:83.3 mg/mL (25 mM)

参考文献

1.Derossi D, et al. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem Biophys Res Commun. 1998;251(1):148-152.
2.Feng X, et al. Graphene oxide induces p62/SQSTM-dependent apoptosis through the impairment of autophagic flux and lysosomal dysfunction in PC12 cells. Acta Biomater. 2018;81:278-29

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