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740 Y-P acetate

CAS号

分子式

C143H226N43O41PS3

主要靶点

PI3K

仅限科研使用

Cat No : CM19943

Print datasheet

Synonyms

PI3K|PDGFR 740Y-P Acetate|740 Y-P Acetate|740 Y-P acetate(1236188-16-1 Free base)|740YPDGFR acetate|740YPDGFR Acetate

验证数据展示

  • CAS No.:

    740 Y-P acetate
    CAS#:

产品信息

CAS号
分子式 C143H226N43O41PS3
主要靶点 PI3K
主要通路 PI3K/Akt/mTOR 信号通路
分子量 3330.79
纯度 ， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 PI3K|PDGFR 740Y-P Acetate|740 Y-P Acetate|740 Y-P acetate(1236188-16-1 Free base)|740YPDGFR acetate|740YPDGFR Acetate

靶点活性

PI3K:20 μM

体外活性

740 Y-P TFA (1 μg/mL) 在测试的最低浓度下促进了有丝分裂。该肽在有无血清(0.5%)的条件下均可刺激有丝分裂，前者情况下，观察到最大反应浓度为50 μg/mL。740Y-P 对有丝分裂的刺激具有高度特异性，这一点与细胞渗透性SH2结合肽的一般特性不同。[1] 当740 Y-P TFA (50 μg/mL; 48小时)加入培养基时，其对有丝分裂的特异性刺激优于EGF或FGF刺激S期进入，显示在C2细胞中S期细胞的百分比为48.3%。此外，LY294002或wortmannin有效抑制了由740Y-P TFA肽刺激的有丝分裂反应。[1] 740 Y-P TFA (30 μM; 24小时) 显著抑制了GO诱导的PC12细胞中LC3-II/LC3-I的水平。[2]

溶解度

H2O:83.3 mg/mL (25 mM);DMSO:83.3 mg/mL (25 mM)

参考文献

1.Derossi D, et al. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem Biophys Res Commun. 1998;251(1):148-152.
2.Feng X, et al. Graphene oxide induces p62/SQSTM-dependent apoptosis through the impairment of autophagic flux and lysosomal dysfunction in PC12 cells. Acta Biomater. 2018;81:278-29

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