验证数据展示
产品信息
67151-1-PBS targets HDAC3 in WB, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.
Tested Applications | WB, Indirect ELISA Application Description |
Tested Reactivity | Human, mouse, rat |
Immunogen | HDAC3 fusion protein Ag28464 种属同源性预测 |
Host / Isotype | Mouse / IgG2b |
Class | Monoclonal |
Type | Antibody |
Full Name | histone deacetylase 3 |
Synonyms | HD3, HDAC, HDAC3, histone deacetylase 3, RPD3, RPD3 2, SMAP45 |
Calculated Molecular Weight | 49 kDa |
Observed Molecular Weight | 49 kDa |
GenBank Accession Number | BC000614 |
Gene Symbol | HDAC3 |
Gene ID (NCBI) | 8841 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | O15379 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the (-amino groups of lysines located near the amino termini of core histone proteins. At least 4 classes of HDAC were identified. HDAC3 is a class I HDAC. HDAC3 has histone deacetylase activity and may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. HDAC3 can also down-regulate p53 function and thus modulate cell growth and apoptosis. The gene encoding HDAC3 is regarded as a potential tumor suppressor gene.