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Host
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Species Reactivity
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Species Reactivity
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Conjugate
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Conjugate
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验证数据展示

  • WB analysis using 81211-1-RR (same clone as 81211-1-PBS)

    WB analysis using 81211-1-RR (same clone as 81211-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 81211-1-RR (HDAC3 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 81211-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver cancer using 81211-1-RR (same clone as 81211-1-PBS)

    IHC staining of human liver cancer using 81211-1-RR (same clone as 81211-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 81211-1-RR (HDAC3 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 81211-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with HDAC3 antibody included
  • IHC staining of human liver cancer using 81211-1-RR (same clone as 81211-1-PBS)

    IHC staining of human liver cancer using 81211-1-RR (same clone as 81211-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 81211-1-RR (HDAC3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 81211-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with HDAC3 antibody included
  • IHC staining of human thyroid cancer using 81211-1-RR (same clone as 81211-1-PBS)

    IHC staining of human thyroid cancer using 81211-1-RR (same clone as 81211-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human thyroid cancer tissue slide using 81211-1-RR (HDAC3 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 81211-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with HDAC3 antibody included
  • IHC staining of human thyroid cancer using 81211-1-RR (same clone as 81211-1-PBS)

    IHC staining of human thyroid cancer using 81211-1-RR (same clone as 81211-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human thyroid cancer tissue slide using 81211-1-RR (HDAC3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 81211-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with HDAC3 antibody included
  • Affinity and Kinetic Characterization of 81211-1-PBS

    Affinity and Kinetic Characterization of 81211-1-PBS

    Biolayer interferometry (BLl) kinetic assays of 81211-1-RR against Human HDAC3 were performed. The affinity constant is 0.213 nM.

HDAC3 Recombinant antibody, PBS Only

HDAC3 Uni-rAbTM Recombinant Antibody for WB, IHC, Indirect ELISA
Cat No. 81211-1-PBS

产品说明书

CloneNo. 2N1

宿主/亚型

Rabbit / IgG

种属反应性

Human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

HD3, HDAC3, histone deacetylase 3, RPD3, RPD3 2, SMAP45

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy HDAC3 Ready-To-Use IHC Kit. HDAC3 primary antibody included.

产品信息

81211-1-PBS targets HDAC3 in WB, IHC, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 Human, mouse, rat
免疫原 HDAC3 fusion protein Ag0396 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 histone deacetylase 3
别名 HD3, HDAC3, histone deacetylase 3, RPD3, RPD3 2, SMAP45
计算分子量 49 kDa
观测分子量49 kDa
GenBank蛋白编号BC000614
基因名称 HDAC3
Gene ID (NCBI) 8841
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDO15379
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the (-amino groups of lysines located near the amino termini of core histone proteins. At least 4 classes of HDAC were identified. HDAC3 is a class I HDAC. HDAC3 has histone deacetylase activity and may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. HDAC3 can also down-regulate p53 function and thus modulate cell growth and apoptosis. The gene encoding HDAC3 is regarded as a potential tumor suppressor gene.