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Ionomycin

Ionomycin 是一种钙离子载体和一种结合钙离子(Ca2+)的抗生素。它是由联合链霉菌(Streptomyces conglobatus)产生的。它在研究中用于提高细胞内钙水平(Ca2+)，并作为了解 Ca2+跨生物膜运输的研究工具。Ionomycin 可促进细胞凋亡，诱导蛋白激酶 C (PKC)活化。

CAS号

56092-81-0

分子式

C41H72O9

主要靶点

Others

仅限科研使用

Cat No : CM06928

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Synonyms

Ionomycin

验证数据展示

  • CAS No.: 56092-81-0

    Ionomycin
    CAS#: 56092-81-0

产品信息

Ionomycin is an calcium ionophore and an antibiotic that binds calcium ions (Ca2+). It is produced by the bacterium Streptomyces conglobatus.It is used in research to raise the intracellular calcium level (Ca2+) and as a research tool to understand Ca2+ transport across biological membranes. Ionomycin promotes apoptosis and induces the activation of protein kinase C (PKC).

CAS号 56092-81-0
分子式 C41H72O9
主要靶点 Others
主要通路 其他
分子量 709.01
纯度 ， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 2 years
别名 Ionomycin

体外活性

Ionomycin (2 μM) induced cell death in LCLC 103H cells, derived from a human large cell lung carcinoma, by inducing calpain activation promotes decrease of Bcl-2 proteins thereby triggering the intrinsic apoptotic pathway [2].Ionomycin also phosphorylate p38 MAPK by Ca2+ influx through SOCE, leading to suppression of TNF-α-induced NF-κB phosphorylation[3].

溶解度

Ethanol: 90.0 mg/mL (126.9 mM), sonification is recommended. DMSO: 90.0 mg/mL (126.9 mM), sonification is recommended.

参考文献

1. Lautens M, et al. Total synthesis of ionomycin using ring-opening strategies. Org Lett. 2002 May 30;4(11):1879-82.
2. Assfalg-Machleidt I,et al. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem. 2002 Jul 26;277(30):27217-26.
3. Uwada J, et al. Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells. Cell Signal. 2019 Nov;63:109358.

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