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Ionomycin

CAS号

56092-81-0

分子式

C41H72O9

主要靶点

Others

仅限科研使用

Cat No : CM06928

Print datasheet

Synonyms

CalciumChannel|Calcium ionophore|Calcium Channel|Ionomycin|离子霉素

验证数据展示

  • CAS No.: 56092-81-0

    Ionomycin
    CAS#: 56092-81-0

产品信息

CAS号 56092-81-0
分子式 C41H72O9
主要靶点 Others
主要通路 代谢|离子通道
分子量 709.01
纯度 99.54%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 CalciumChannel|Calcium ionophore|Calcium Channel|Ionomycin|离子霉素

体外活性

Ionomycin (2 μM) 在来源于人类大细胞肺癌的LCLC 103H细胞中诱导细胞死亡，这一过程通过激活calpain促进Bcl-2蛋白的降解，从而触发内源性凋亡途径[2]。Ionomycin还能通过SOCE引起的Ca2+流入磷酸化p38 MAPK，进而抑制TNF-α诱导的NF-κB磷酸化[3]。

溶解度

DMSO:90.0 mg/mL (126.9 mM);Ethanol:90.0 mg/mL (126.9 mM)

参考文献

1.Lautens M, et al. Total synthesis of ionomycin using ring-opening strategies. Org Lett. 2002 May 30;4(11):1879-82.
2.Assfalg-Machleidt I,et al. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem. 2002 Jul 26;277(30):27217-26.
3.Uwada J, et al. Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells. Cell Signal. 2019 Nov;63:109358.

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The dilution calculator equation

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