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Progabide

Progabide (SL 76002) 是一种 γ-氨基丁酸 (GABA) 受体激动剂。

CAS号

62666-20-0

分子式

C17H16ClFN2O2

主要靶点

GABA Receptor

仅限科研使用

Cat No : CM14744

Print datasheet

Synonyms

Gabren|Gabrene|SL 76002|Halogabide

验证数据展示

  • CAS No.: 62666-20-0

    Progabide
    CAS#: 62666-20-0

产品信息

Progabide is an agonist of the gamma-aminobutyric acid receptor.

CAS号 62666-20-0
分子式 C17H16ClFN2O2
主要靶点 GABA Receptor
主要通路 离子通道|神经科学
分子量 334.77
纯度 99.70%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Gabren|Gabrene|SL 76002|Halogabide

体内活性

Progabide ( 50, 100 and 200 mg/kg) given IP to male Wistar rats enhance the plasma corticosterone levels by 244, 365, and 476% respectively (t=6.44 to12.55, p<0.01). Progabide (10 mg/kg) fails to change the concentration of corticosterone in plasma (t=0.76, N.S.). The increased plasma corticosterone level induced by administration of 200 mg/kg Progabide is evident 30 (t=2.625, p<0.05), 60 (t=13.13, p<0.001) and 120 min (t=4.07, p<0.01) after drug injection, but returns to the control value 240 min after drug injection (t=0.86, N.S.). Compare with the corresponding control, The greatest corticosterone rise is reached 60 min following the administration of Progabide[1].

溶解度

DMSO:225mg/mL (672.1mM),Sonification is recommended.

参考文献

1.Manev H, et al. Progabide, a GABA mimetic drug, stimulates the secretion of plasma corticosterone in rats. Pharmacol Biochem Behav. 1987 Dec;28(4):443-6.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2