CoraLite® Plus 488-conjugated ROR1 Monoclonal antibody
ROR1 Monoclonal Antibody for
Host / Isotype
Mouse / IgG1
Reactivity
Human
Applications
Conjugate
CoraLite® Plus 488 Fluorescent Dye
CloneNo.
1F5D8
验证数据展示
Planning an IHC experiment? We recommend our IHCeasy ROR1 Ready-To-Use IHC Kit. ROR1 primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 66923-1-Ig
产品信息
CL488-66923 targets ROR1 in applications and shows reactivity with Human samples.
| Tested Applications | Application Description |
| Tested Reactivity | Human |
| Immunogen | ROR1 fusion protein Ag14586 种属同源性预测 |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | receptor tyrosine kinase-like orphan receptor 1 |
| Synonyms | ROR1, 1F5D8, Inactive tyrosine-protein kinase transmembrane receptor ROR1, Neurotrophic tyrosine kinase, receptor-related 1, NTRKR1 |
| Calculated Molecular Weight | 937 aa, 104 kDa |
| Observed Molecular Weight | 130 kDa |
| GenBank Accession Number | BC006374 |
| Gene Symbol | ROR1 |
| Gene ID (NCBI) | 4919 |
| RRID | AB_2919388 |
| Conjugate | CoraLite® Plus 488 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 493 nm / 522 nm |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | Q01973 |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
ROR1 is a member of the RTK family of orphan receptors related to muscle specific kinase and Trk neurotrophin receptors (PMID: 18546292). ROR1 is primarily expressed by neural crest cells during embryogenesis. High expression of ROR1 is reported in many types of malignancies and is thought to be involved in tumor growth, apoptosis, and epithelial-mesenchymal transition (PMID: 26245996). The human ROR1 gene encodes a 937-amino acid protein with an Ig-like domain, a cysteine-rich domain, a kringle domain, a tyrosine kinase domain and a proline-rich domain. The calculated molecular weight of ROR1 is 104 kDa, but ROR1 has multiple N-glycosylation sites that generate post-translationally modified ROR1 at 130 kDa (PMID: 24752542).
