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  • KD/KO Validated

TRPC1 Polyclonal antibody

TRPC1 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

ELISA and More (3)

Conjugate

Unconjugated

Cat no : 19482-1-AP

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Synonyms

HTRP 1, Transient receptor protein 1, TRP 1, TRP1, TRPC1



经过测试的应用

Positive WB detected inPC-3 cells, human brain tissue, human testis tissue, mouse liver tissue, SH-SY5Y cells
Positive IHC detected inhuman brain tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:500-1:2000
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

19482-1-AP targets TRPC1 in WB, IP, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications ELISA Application Description
Cited ApplicationsWB, IP, IF
Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse, rat
Immunogen Peptide 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name transient receptor potential cation channel, subfamily C, member 1
Synonyms HTRP 1, Transient receptor protein 1, TRP 1, TRP1, TRPC1
Calculated Molecular Weight 91 kDa
Observed Molecular Weight 90 kDa, 130 kDa
GenBank Accession NumberNM_003304
Gene Symbol TRPC1
Gene ID (NCBI) 7220
RRIDAB_10642834
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDP48995
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

TRPC1, also named as TRP1, belongs to the transient receptor family and STrpC subfamily. TRPC1 is thought to form a receptor-activated non-selective calcium permeant cation channel. It has been reported that the mGluR1 evoked slow EPSC is mediated by the TRPC1 cation channel. It is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.

实验方案

Product Specific Protocols
WB protocol for TRPC1 antibody 19482-1-APDownload protocol
IHC protocol for TRPC1 antibody 19482-1-APDownload protocol
IF protocol for TRPC1 antibody 19482-1-APDownload protocol
FC protocol for TRPC1 antibody 19482-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
humanWB

Cell Res

Direct control of store-operated calcium channels by ultrafast laser.

Authors - Pan Cheng
  • KD Validated
mouseWB,IF

J Neuroinflammation

Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice.

Authors - Shiji Huo
humanWB

J Biomed Sci

Chemoresistant ovarian cancer enhances its migration abilities by increasing store-operated Ca2+ entry-mediated turnover of focal adhesions.

Authors - Ho-Kai Huang
ratWB

Sci Rep

Homer binds to Orai1 and TRPC channels in the neointima and regulates vascular smooth muscle cell migration and proliferation.

Authors - Shuping Jia
ratWB

J Biochem Mol Toxicol

Galectin-3 mediates pulmonary vascular endothelial cell dynamics via TRPC1/4 under acute hypoxia.

Authors - Yumei Li
mouseWB

Int J Mol Sci

STIM1 Knockout Enhances PDGF-Mediated Ca2+ Signaling through Upregulation of the PDGFR⁻PLCγ⁻STIM2 Cascade.

Authors - Tzu-Yu Huang