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ChromoTek anti-FGF-9 recombinant VHH, for 1x Cys conjugation

fgf9Cys1 is an unconjugated recombinant anti FGF9 Nanobody (VHH). Suitable for for dual cysteine conjugation with thiol-reactive reagents, e.g. maleimides. Note: unconjugated VHHs are not suited for usage without prior labeling, since they contain reactive Cysteines. Shipment and storage buffers contain TCEP to keep Cysteines reduced.

Host/Type

Alpaca VHH

Reactivity

Human

Applications

Conjugation

Conjugate

Unconjugated

Cat No : fgf9Cys1

Synonyms

FGF9-VHH, FGF9 single domain antibody (sdAb), FGF9, FGF-9

Validation Data Gallery

Product Information

fgf9Cys1 is an unconjugated recombinant anti FGF9 Nanobody (VHH). Suitable for for dual cysteine conjugation with thiol-reactive reagents, e.g. maleimides. Note: unconjugated VHHs are not suited for usage without prior labeling, since they contain reactive Cysteines. Shipment and storage buffers contain TCEP to keep Cysteines reduced.

ApplicationsConjugation
ReactivityHuman
ConjugateUnconjugated
TypeNanobody
ClassRecombinant
HostAlpaca
Affinity/
Molecular Weight14.8 kDa
FormLiquid
RRIDAB_3665412
Storage Buffer10 mM HEPES pH 7.0, 500 mM NaCl, 0.09% sodium azide
Storage ConditionStore at -20°C
Shippingdry ice
BackgroundFGF-9 is a 26 kdA, glycosylated protein that is a member of the FGF superfamily. It primarily binds with FGFR3 and plays prominent roles in the regulating embryonic, lung, and skeletal development. It is a key regulator of male sex determination through promoting the proliferation of pre-Sertoli cells. It signals in conjunction with FGF-10 and SHH to drive the development of the lung mesenchymal space. FGF-9 is also a positive regulator of chondrocyte proliferation and osteogenesis during the bone formation process. Overexpression of loss of FGF-9 during skeletal development often results in aberrant bone growth. (PMID: 28395336, 25772309, 16540513, 25435023).