- HEK293 expressed
- Endotoxin-free
- Animal-component free
HumanKine® recombinant human OSM protein
Activity
0.1-1.5 ng/mL EC50
Specific Activity
3.07 x 107 IU/mg
Species Reactivity
human
Purity
>95%
Validation Data Gallery
Technical Specifications
GeneID | 5008 |
Species | Human |
Expression | HEK293 |
Activity | 0.1-1.5 ng/mL EC50 |
Specific Activity | 3.07 x 107 IU/mg |
Purity | >95% |
Endotoxin | <1 EU/μg |
Accession Number | P13725 |
Molecular Mass | 30 kDa, monomer, glycosylated |
Formulation | 1x PBS, See Certificate of Analysis for details |
Species Reactivity | human |
Stability and Reconstitution
Stability and Storage | Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products. |
Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS pH 7.4 containing 0.1% endotoxin-free recombinant human serum albumin (HSA). |
Background
Oncostatin M (OSM) is a member of a cytokine family that includes a leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM is a growth regulator which inhibits the proliferation of some tumor cell lines. It can stimulate proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF, and GM-CSF from endothelial cells. OSM is involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (PMID: 9133674; 29526757; 29363180; 21887386).
Synonyms
oncostatin M, OSM
Publications
Species | Title |
---|---|
Oncotarget CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia. | |
Invest Ophthalmol Vis Sci Role of Oncostatin M in the Pathogenesis of Vernal Keratoconjunctivitis: Focus on the Barrier Function of the Epithelium and Interleukin-33 Production by Fibroblasts | |
Cancer Biomark Interleukin-6 and oncostatin M are elevated in liver disease in conjunction with candidate hepatocellular carcinoma biomarker GP73. | |
Front Pharmacol A Novel Naphthoquinone-Coumarin Hybrid That Inhibits BCR-ABL1-STAT5 Oncogenic Pathway and Reduces Survival in Imatinib-Resistant Chronic Myelogenous Leukemia Cells. |