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ACVR1 Monoclonal antibody, PBS Only

ACVR1 Monoclonal Antibody for WB,Indirect ELISA,IHC,IF

Host / Isotype

Mouse / IgG2a

Reactivity

Human, Pig, Mouse, Rat

Applications

WB,Indirect ELISA,IHC,IF

Conjugate

Unconjugated

CloneNo.

1F11B10

Cat No : 67417-1-PBS

Print datasheet

Synonyms

activin A receptor, type I, Activin receptor like kinase 2, Activin receptor type 1, Activin receptor type I, ACTR I, ACTRI, ACVR1, ACVR1A, ACVRLK2, ALK 2, ALK2, FOP, SKR1, TSR I, TSRI

验证数据展示

  • WB analysis using 67417-1-Ig (same clone as 67417-1-PBS)

    WB analysis using 67417-1-Ig (same clone as 67417-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67417-1-Ig (ACVR1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67417-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse heart using 67417-1-Ig (same clone as 67417-1-PBS)

    IHC staining of mouse heart using 67417-1-Ig (same clone as 67417-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 67417-1-Ig (ACVR1 antibody) at dilution of 1:300 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67417-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse heart using 67417-1-Ig (same clone as 67417-1-PBS)

    IHC staining of mouse heart using 67417-1-Ig (same clone as 67417-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 67417-1-Ig (ACVR1 antibody) at dilution of 1:300 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67417-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse brain using 67417-1-Ig (same clone as 67417-1-PBS)

    IF Staining of mouse brain using 67417-1-Ig (same clone as 67417-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using ACVR1 antibody (67417-1-Ig, Clone: 1F11B10 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 67417-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse brain using 67417-1-Ig (same clone as 67417-1-PBS)

    IF Staining of mouse brain using 67417-1-Ig (same clone as 67417-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using ACVR1 antibody (67417-1-Ig, Clone: 1F11B10 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 67417-1-PBS in a different storage buffer formulation.

产品信息

67417-1-PBS targets ACVR1 in WB, IF, IHC, Indirect ELISA applications and shows reactivity with Human, Pig, Mouse, Rat samples.

Tested Applications WB,Indirect ELISA,IHC,IF Application Description
Tested Reactivity Human, Pig, Mouse, Rat
Immunogen ACVR1 fusion protein Ag13508 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name activin A receptor, type I
Synonyms activin A receptor, type I, Activin receptor like kinase 2, Activin receptor type 1, Activin receptor type I, ACTR I, ACTRI, ACVR1, ACVR1A, ACVRLK2, ALK 2, ALK2, FOP, SKR1, TSR I, TSRI
Calculated Molecular Weight 509 aa, 57 kDa
Observed Molecular Weight 57 kDa
GenBank Accession NumberBC033867
Gene Symbol ACVR1
Gene ID (NCBI) 90
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ04771
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

ACVR1 (activin receptor type I), also known as ALK2 or ACTRI, is a receptor for activin. It forms a stable complex with type II receptor after ligand binding. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. ACVR1 is expressed in many tissues including skeletal muscle and chondrocytes. It functions as a receptor for bone morphogenetic protein (BMP) and induces Indian hedgehog in chondrocytes during skeletal development. Mutations in ACVR1 gene are associated with fibrodysplasia ossificans progressive (PMID: 16642017).