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Species Reactivity
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Species Reactivity
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Conjugate
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验证数据展示

  • WB analysis using 67417-1-Ig (same clone as 67417-1-PBS)

    WB analysis using 67417-1-Ig (same clone as 67417-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67417-1-Ig (ACVR1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67417-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse heart using 67417-1-Ig (same clone as 67417-1-PBS)

    IHC staining of mouse heart using 67417-1-Ig (same clone as 67417-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 67417-1-Ig (ACVR1 antibody) at dilution of 1:300 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67417-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with ACVR1 antibody included
  • IHC staining of mouse heart using 67417-1-Ig (same clone as 67417-1-PBS)

    IHC staining of mouse heart using 67417-1-Ig (same clone as 67417-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 67417-1-Ig (ACVR1 antibody) at dilution of 1:300 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67417-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with ACVR1 antibody included
  • IF Staining of mouse brain using 67417-1-Ig (same clone as 67417-1-PBS)

    IF Staining of mouse brain using 67417-1-Ig (same clone as 67417-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using ACVR1 antibody (67417-1-Ig, Clone: 1F11B10 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 67417-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse brain using 67417-1-Ig (same clone as 67417-1-PBS)

    IF Staining of mouse brain using 67417-1-Ig (same clone as 67417-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using ACVR1 antibody (67417-1-Ig, Clone: 1F11B10 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 67417-1-PBS in a different storage buffer formulation.

ACVR1 Monoclonal antibody, PBS Only

ACVR1 Monoclonal Antibody for WB, IHC, IF-P, Indirect ELISA
Cat No. 67417-1-PBS

产品说明书

CloneNo. 1F11B10

宿主/亚型

Mouse / IgG2a

种属反应性

Human, Pig, Mouse, Rat

应用

WB, IHC, IF-P, Indirect ELISA

别名

activin A receptor, type I, Activin receptor like kinase 2, Activin receptor type 1, Activin receptor type I, ACTR I, ACTRI, ACVR1, ACVR1A, ACVRLK2, ALK 2, ALK2, FOP, SKR1, TSR I, TSRI

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy ACVR1 Ready-To-Use IHC Kit. ACVR1 primary antibody included.

产品信息

67417-1-PBS targets ACVR1 in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with Human, Pig, Mouse, Rat samples.

经测试应用 WB, IHC, IF-P, Indirect ELISA Application Description
经测试反应性 Human, Pig, Mouse, Rat
免疫原 ACVR1 fusion protein Ag13508 种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 activin A receptor, type I
别名 activin A receptor, type I, Activin receptor like kinase 2, Activin receptor type 1, Activin receptor type I, ACTR I, ACTRI, ACVR1, ACVR1A, ACVRLK2, ALK 2, ALK2, FOP, SKR1, TSR I, TSRI
计算分子量 509 aa, 57 kDa
观测分子量 57 kDa
GenBank蛋白编号BC033867
基因名称 ACVR1
Gene ID (NCBI) 90
RRIDAB_2882657
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ04771
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ACVR1 (activin receptor type I), also known as ALK2 or ACTRI, is a receptor for activin. It forms a stable complex with type II receptor after ligand binding. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. ACVR1 is expressed in many tissues including skeletal muscle and chondrocytes. It functions as a receptor for bone morphogenetic protein (BMP) and induces Indian hedgehog in chondrocytes during skeletal development. Mutations in ACVR1 gene are associated with fibrodysplasia ossificans progressive (PMID: 16642017).