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验证数据展示

  • WB analysis using 60342-1-Ig (same clone as 60342-1-PBS)

    WB analysis using 60342-1-Ig (same clone as 60342-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 60342-1-Ig (APP antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60342-1-PBS in a different storage buffer formulation.

  • WB analysis of Y79 using 60342-1-Ig (same clone as 60342-1-PBS)

    WB analysis of Y79 using 60342-1-Ig (same clone as 60342-1-PBS)

    Y79 cells were subjected to SDS PAGE followed by western blot with 60342-1-Ig (APP Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60342-1-PBS in a different storage buffer formulation.

  • IHC staining of human gliomas using 60342-1-Ig (same clone as 60342-1-PBS)

    IHC staining of human gliomas using 60342-1-Ig (same clone as 60342-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 60342-1-Ig (APP Antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 60342-1-PBS in a different storage buffer formulation.

  • IHC staining of human gliomas using 60342-1-Ig (same clone as 60342-1-PBS)

    IHC staining of human gliomas using 60342-1-Ig (same clone as 60342-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 60342-1-Ig (APP Antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 60342-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

APP Monoclonal antibody, PBS Only

APP Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 60342-1-PBS

产品说明书

CloneNo. 5C2A1

宿主/亚型

Mouse / IgG2a

种属反应性

human, rat, pig, rabbit

应用

WB, IHC, Indirect ELISA

别名

amyloid precursor protein, Alzheimer disease amyloid A4 protein homolog, AD1, AB42, AB40

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

60342-1-PBS targets APP in WB, IHC, Indirect ELISA applications and shows reactivity with human, rat, pig, rabbit samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, rat, pig, rabbit
免疫原 APP fusion protein Ag0769 种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 amyloid beta (A4) precursor protein
别名 amyloid precursor protein, Alzheimer disease amyloid A4 protein homolog, AD1, AB42, AB40
计算分子量 87 kDa
观测分子量 100 kDa
GenBank蛋白编号BC004369
基因名称 APP
Gene ID (NCBI) 351
RRIDAB_2881451
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP05067
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Aβ derives from APP via proteolytic cleavage by proteases called α-, β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ, while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein(APP), encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 (AD1).