验证数据展示
产品信息
60342-1-PBS targets APP in WB, IHC, Indirect ELISA applications and shows reactivity with human, rat, pig, rabbit samples.
Tested Applications | WB, IHC, Indirect ELISA Application Description |
Tested Reactivity | human, rat, pig, rabbit |
Immunogen | APP fusion protein Ag0769 种属同源性预测 |
Host / Isotype | Mouse / IgG2a |
Class | Monoclonal |
Type | Antibody |
Full Name | amyloid beta (A4) precursor protein |
Synonyms | amyloid precursor protein, Alzheimer disease amyloid A4 protein homolog, AD1, AB42, AB40 |
Calculated Molecular Weight | 87 kDa |
Observed Molecular Weight | 100 kDa |
GenBank Accession Number | BC004369 |
Gene Symbol | APP |
Gene ID (NCBI) | 351 |
RRID | AB_2881451 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | P05067 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Aβ derives from APP via proteolytic cleavage by proteases called α-, β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ, while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein(APP), encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 (AD1).