CD41/Integrin alpha 2b Monoclonal antibody

CD41/Integrin alpha 2b Monoclonal Antibody for WB, ELISA
Cat No. 60350-1-Ig

产品说明书

CloneNo. 6D7C5

宿主/亚型

Mouse / IgG1

种属反应性

human

应用

WB, ELISA

CD41, CD41/Integrin alpha 2b, CD41B, GP2B, GPalpha IIb, GPIIb, GTA, HPA3, Integrin alpha IIb, ITGA2B, ITGAB

缓冲液配方:  PBS and Azide
PBS and Azide
PBS Only
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -


经过测试的应用

Positive WB detected inhuman spleen tissue

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:500-1:3200
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

发表文章中的应用

WBSee 1 publications below

产品信息

60350-1-Ig targets CD41/Integrin alpha 2b in WB, ELISA applications and shows reactivity with human samples.

经测试应用 WB, ELISA Application Description
文献引用应用WB
经测试反应性 human
文献引用反应性human
免疫原 Peptide 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
别名 CD41, CD41/Integrin alpha 2b, CD41B, GP2B, GPalpha IIb, GPIIb, GTA, HPA3, Integrin alpha IIb, ITGA2B, ITGAB
计算分子量 113 kDa
观测分子量 125 kDa
GenBank蛋白编号BC126442
基因名称 CD41a
Gene ID (NCBI) 3674
RRIDAB_2881459
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein G purification
UNIPROT IDP08514
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866). This protein undergoes post-translational cleavage to yield disulfide linked light (25 kDa) and heavy (125 kDa) chains which join with integrin beta3 (CD61) to form a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrin alpha-IIb/beta-3 is crucial for platelet aggregation through binding of soluble fibrinogen.

实验方案

Product Specific Protocols
WB protocol for CD41/Integrin alpha 2b antibody 60350-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
humanWB

Commun Biol

In-situ gelation of fibrin gel encapsulating platelet-rich plasma-derived exosomes promotes rotator cuff healing

Authors - Molin Li
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