Validation Data Gallery
Technical Specifications
| GeneID | 655 |
| Species | Human |
| Expression | HEK293 |
| Activity | 50-275 ng/mL |
| Purity | >95% |
| Endotoxin | <1 EU/µg |
| Accession Number | P18075 |
| Molecular Mass | 20 kDa reduced, 32 to 36 kDa non-reduced, homodimer, glycosylated |
| Formulation | 10mM Acetic Acid |
| Species Reactivity | human,mouse |
Stability and Reconstitution
| Stability and Storage | Product Form | Temperature Conditions | Storage Time (From Date of Receipt) |
|---|---|---|---|
| Lyophilized | -20°C to -80°C | Until Expiry Date | |
| Lyophilized | Room Temperature | 2 weeks | |
| Reconstituted as per CofA | -20°C to -80°C | 6 months | |
| Reconstituted as per CofA | 4°C | 1 week | |
| Avoid repeated freeze-thaw cycles. | |||
| Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in 10mM Acetic Acid containing 0.1% endotoxin-free recombinant human serum albumin (HSA). Gently swirl or tap vial to mix. |
Background
Bone morphogenetic protein-7 (BMP7), also known as osteogenic protein-1 or OP-1, plays a key role in the differentiation of mesenchymal cells into bone and cartilage. BMP7 may be involved in bone homeostasis (PMID: 15621726). It is expressed in the brain, kidneys and bladder. BMP7 is also present in several cancers, including breast, prostate, and colon cancers (PMID: 16419056, PMID: 15531927). Overexpression of BMP7 mRNA in colorectal cancer patients is significantly associated with poor prognosis and low overall survival (PMID: 18259822). Recent studies suggest that high-expression level of BMP7 serves as a biomarker for poor prognosis for HCC (PMID: 23179403).
Synonyms
BMP 7, BMP7, BMP-7, bone morphogenetic protein 7, Eptotermin alfa, HZ1229, OP 1, OP1, Osteogenic protein 1
Publications
| Species | Title |
|---|---|
Cell Mol Gastroenterol Hepatol Over-expressed Phospholamban in Cancer Associated Fibroblasts is a Driver for CMS4 Subtype Colorectal Cancer Formation | |
Stem Cell Res Ther Generation of special autosomal dominant polycystic kidney disease iPSCs with the capability of functional kidney-like cell differentiation. | |
Cell Rep Paracrine stimulation of brown adipose tissue vascularization by adipocyte O-GlcNAc signaling. | |
Sci Rep The TRAF6/SPP1 axis participates in osteoarthritis progression through regulating the catabolism and anabolism of cartilage matrix. | |
Biomed Mater Osteogenic differentiation system based on biopolymer nanoparticles for stem cells in simulated microgravity. | |
