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验证数据展示

  • IHC staining of human kidney using 80063-1-RR (same clone as 80063-1-PBS)

    IHC staining of human kidney using 80063-1-RR (same clone as 80063-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 80063-1-RR (ACE2 antibody) at dilution of 1:1500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 80063-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with ACE2 antibody included
  • IHC staining of human kidney using 80063-1-RR (same clone as 80063-1-PBS)

    IHC staining of human kidney using 80063-1-RR (same clone as 80063-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 80063-1-RR (ACE2 antibody) at dilution of 1:1500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 80063-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with ACE2 antibody included
  • IF Staining of human kidney using 80063-1-RR (same clone as 80063-1-PBS)

    IF Staining of human kidney using 80063-1-RR (same clone as 80063-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed human kidney tissue using ACE2 antibody (80063-1-RR, Clone: 4H12 ) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 80063-1-PBS in a different storage buffer formulation.

ACE2 Recombinant antibody, PBS Only

ACE2 Uni-rAbTM Recombinant Antibody for IHC, IF-P, Indirect ELISA
Cat No. 80063-1-PBS

产品说明书

CloneNo. 4H12

宿主/亚型

Rabbit / IgG

种属反应性

Human

应用

IHC, IF-P, Indirect ELISA

别名

ACE related carboxypeptidase, ACE2, ACEH, DKFZp434A014, Metalloprotease MPROT15

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy ACE2 Ready-To-Use IHC Kit. ACE2 primary antibody included.

产品信息

80063-1-PBS targets ACE2 in IHC, IF-P, Indirect ELISA applications and shows reactivity with Human samples.

经测试应用 IHC, IF-P, Indirect ELISA Application Description
经测试反应性 Human
免疫原 ACE2 fusion protein Ag30683 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
别名 ACE related carboxypeptidase, ACE2, ACEH, DKFZp434A014, Metalloprotease MPROT15
计算分子量 805 aa, 92 kDa
GenBank蛋白编号BC048094
基因名称 ACE2
Gene ID (NCBI) 59272
RRIDAB_2918860
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ9BYF1
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ACE2 (Angiotensin-converting enzyme 2), also named as ACEH, is a zinc metalloprotease of the ACE family and a critical regulator of the reninangiotensin system. ACE2 has a more restricted tissue distribution than ACE, being found predominantly in the heart, kidneys, and testes although low levels have been detected in a variety of tissues (PMID:15983030). ACE2 has been shown to be a functional receptor of the human coronaviruses SARS-CoV and SARS-CoV-2 (PMID: 32142651). The expression level and expression pattern of human ACE2 in different tissues might be critical for the susceptibility, symptoms, and outcome of 2019-nCoV/SARS-CoV-2 infection (PMID: 32133153). It can be used as a potential therapeutic target of SARS-CoV-2 (PMID: 32125455). The calculated molecular weight of ACE2 is 92kDa but it migrates to 120kDa due to N-glycosylation (PMID:16166094). Sometimes, several cleaved fragments can also be detected as 75kDa, 50 kDa or 37kDa (PMID: 29561187, 22009550, 30759273). It has 2 isoforms produced by alternative splicing. This antibody is specific to ACE2. The location of ACE2 is membrane and cytoplasm, however it accumulates in the nucleus during the mitosis (PMID: 1730413/PMID: 18292088). 80063-1-RR is specific for ACE2, and its antigen region is 30-356aa.