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AGTR1 Monoclonal antibody, PBS Only

AGTR1 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

human, mouse, rat, pig

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2C5G11

Cat no : 66415-1-PBS

Print datasheet

Synonyms

Angiotensin II type-1 receptor, Angiotensin II type 1 receptor, AGTR1B, AGTR1A, AG2S

验证数据展示

  • WB analysis of pig heart using 66415-1-Ig (same clone as 66415-1-PBS)

    WB analysis of pig heart using 66415-1-Ig (same clone as 66415-1-PBS)

    pig heart tissue were subjected to SDS PAGE followed by western blot with 66415-1-Ig (AGTR1 Antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66415-1-PBS in a different storage buffer formulation.

产品信息

66415-1-PBS targets AGTR1 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat, pig samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human, mouse, rat, pig
Immunogen AGTR1 fusion protein Ag14461 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name angiotensin II receptor, type 1
Synonyms Angiotensin II type-1 receptor, Angiotensin II type 1 receptor, AGTR1B, AGTR1A, AG2S
Calculated Molecular Weight 359 aa, 41 kDa
Observed Molecular Weight 50 kDa
GenBank Accession NumberBC022447
Gene Symbol AGTR1
Gene ID (NCBI) 185
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP30556
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Angiotensin II (Ang II), the main effector molecule of the renin-angiotensin system, exerts its actions mainly via interaction with type-1 angiotensin II receptor (AGTR1, also named as AT1R), thereby contributing to blood pressure regulation. AGTR1 mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. By regulating vascular tone, cardiovascular function, salt and water homeostasis, AGTR1 exerts an indispensable physiological role (PMID: 21600887). AGTR1 has been implicated in diverse aspects of human disease, from the regulation of blood pressure and cardiovascular homeostasis to cancer progression (PMID: 26975580).