验证数据展示
产品信息
12526-1-AP targets FE65 in ELISA applications and shows reactivity with human samples.
| Tested Applications | ELISA Application Description |
| Tested Reactivity | human |
| Immunogen | FE65 fusion protein Ag3221 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Full Name | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) |
| Synonyms | APBB1, FE65, Protein Fe65, RIR |
| Calculated Molecular Weight | 708 aa, 77 kDa |
| GenBank Accession Number | BC010854 |
| Gene Symbol | APBB1 |
| Gene ID (NCBI) | 322 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | O00213 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
APBB1 is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression.