CD11B/Integrin Alpha M Monoclonal antibody, PBS Only

CD11B/Integrin Alpha M Monoclonal Antibody for WB, IHC, IF-P, ELISA
Cat No. 66519-1-PBS

产品说明书

CloneNo. 1C7C2

宿主/亚型

Mouse / IgG2b

种属反应性

human

应用

WB, IHC, IF-P, ELISA

CD11b, CR-3 alpha chain, CR 3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, CD11 antigen-like family member B

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -


Planning an IHC experiment? We recommend our IHCeasy CD11B Ready-To-Use IHC Kit. CD11B primary antibody included.

产品信息

66519-1-PBS targets CD11B/Integrin Alpha M in WB, IHC, IF-P, ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IF-P, ELISA Application Description
经测试反应性 human
免疫原 Peptide 种属同源性预测
宿主/亚型 Mouse / IgG2b
抗体类别 Monoclonal
产品类型 Antibody
全称 integrin, alpha M (complement component 3 receptor 3 subunit)
别名 CD11b, CR-3 alpha chain, CR 3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, CD11 antigen-like family member B
计算分子量 93 kDa
观测分子量 160 kDa
GenBank蛋白编号NM_000632
基因名称 CD11b
Gene ID (NCBI) 3684
ENSEMBL Gene IDENSG00000169896
RRIDAB_2881882
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP11215
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828).

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