验证数据展示
产品信息
66519-1-PBS targets CD11B/Integrin Alpha M in WB, IHC, IF-P, ELISA applications and shows reactivity with human samples.
经测试应用 | WB, IHC, IF-P, ELISA Application Description |
经测试反应性 | human |
免疫原 | Peptide 种属同源性预测 |
宿主/亚型 | Mouse / IgG2b |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | integrin, alpha M (complement component 3 receptor 3 subunit) |
别名 | CD11b, CR-3 alpha chain, CR 3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, CD11 antigen-like family member B |
计算分子量 | 93 kDa |
观测分子量 | 160 kDa |
GenBank蛋白编号 | NM_000632 |
基因名称 | CD11b |
Gene ID (NCBI) | 3684 |
ENSEMBL Gene ID | ENSG00000169896 |
RRID | AB_2881882 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | P11215 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828).