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  • Featured Product
  • KD/KO Validated

CD206 Monoclonal antibody, PBS Only

CD206 Monoclonal Antibody for WB,IP,IHC,IF,ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

human

Applications

WB,IP,IHC,IF,ELISA

Conjugate

Unconjugated

CloneNo.

2A6A10

Cat No : 60143-1-PBS

Print datasheet

Synonyms

CD206, CLEC13D, Macrophage mannose receptor 1, Mannose receptor, mannose receptor, C type 1, MMR, MRC1

验证数据展示

  • WB analysis of human placenta using 60143-1-Ig (same clone as 60143-1-PBS)

    WB analysis of human placenta using 60143-1-Ig (same clone as 60143-1-PBS)

    human placenta tissue was subjected to SDS PAGE followed by western blot with 60143-1-Ig (CD206 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60143-1-PBS in a different storage buffer formulation.

  • IHC staining of human lung cancer using 60143-1-Ig (same clone as 60143-1-PBS)

    IHC staining of human lung cancer using 60143-1-Ig (same clone as 60143-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 60143-1-Ig (CD206 antibody) at dilution of 1:20000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 60143-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with CD206 antibody included
  • IHC staining of human lung cancer using 60143-1-Ig (same clone as 60143-1-PBS)

    IHC staining of human lung cancer using 60143-1-Ig (same clone as 60143-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 60143-1-Ig (CD206 antibody) at dilution of 1:20000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 60143-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with CD206 antibody included
  • IF Staining of human lung cancer using 60143-1-Ig (same clone as 60143-1-PBS)

    IF Staining of human lung cancer using 60143-1-Ig (same clone as 60143-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed human lung cancer tissue using CD206 antibody (60143-1-Ig, Clone: 2A6A10 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 60143-1-PBS in a different storage buffer formulation.

  • IF Staining of human lung cancer using 60143-1-Ig (same clone as 60143-1-PBS)

    IF Staining of human lung cancer using 60143-1-Ig (same clone as 60143-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed human lung cancer tissue using CD206 antibody (60143-1-Ig, Clone: 2A6A10 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 60143-1-PBS in a different storage buffer formulation.

  • IP experiment of human placenta using 60143-1-Ig (same clone as 60143-1-PBS)

    IP experiment of human placenta using 60143-1-Ig (same clone as 60143-1-PBS)

    IP result of anti-CD206 (IP:60143-1-Ig, 5ug; Detection:60143-1-Ig 1:300) with human placenta tissue lysate 1520ug. This data was developed using the same antibody clone with 60143-1-PBS in a different storage buffer formulation.

Planning an IHC experiment? We recommend our IHCeasy CD206 Ready-To-Use IHC Kit. CD206 primary antibody included.

产品信息

60143-1-PBS targets CD206 in WB, IP, IF, IHC, ELISA applications and shows reactivity with human samples.

Tested Applications WB,IP,IHC,IF,ELISA Application Description
Tested Reactivity human
Immunogen Peptide 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name mannose receptor, C type 1
Synonyms CD206, CLEC13D, Macrophage mannose receptor 1, Mannose receptor, mannose receptor, C type 1, MMR, MRC1
Calculated Molecular Weight 166 kDa
Observed Molecular Weight 170 kDa
GenBank Accession NumberNM_002438
Gene Symbol MRC1
Gene ID (NCBI) 4360
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP22897
Storage Buffer PBS only
Storage ConditionsStore at -80°C.

背景介绍

CD206, also named as MMR, CLEC13D and MRC1, is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages, in vitro derived dendritic cells, lymphatic and sinusoidal endothelia. This antibody recognizes the intracellular carboxy-terminal part of CD206 and MRC1L1.