|Positive WB detected in||serum from mouse injected with bacteria, pig liver tissue, rat liver tissue, serum from mouse injected with bacteria tissue|
|Positive IHC detected in||human liver tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in||human liver tissue|
|Western Blot (WB)||WB : 1:2000-1:10000|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
66250-1-Ig targets CRP in WB, IHC, IF,ELISA applications and shows reactivity with human, mouse, rat, pig samples.
|Tested Applications||IF, IHC, WB,ELISA|
|Cited Applications||IHC, WB|
|Tested Reactivity||human, mouse, rat, pig|
|Cited Reactivity||human, mouse, rat|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||CRP fusion protein Ag9883|
|Full Name||C-reactive protein, pentraxin-related|
|Synonyms||C reactive protein, CRP, PTX1|
|Calculated molecular weight||224 aa, 25 kDa|
|Observed molecular weight||27 kDa|
|GenBank accession number||BC020766|
|Uniprot||P02741||Gene ID (NCBI)||1401|
|Purification Method||Protein A purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
C-reactive protein (CRP) is an acute-phase serum protein synthesized by the liver in response to interleukin-6 (IL-6) during inflammation. The name of CRP derives from its ability to react with the C polysaccharide of Streptococcus pneumoniae. CRP is an annular, pentameric protein that belongs to the pentraxin family of proteins. CRP displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. It is used mainly as a marker of inflammation.
Prenatal stress induced depressive-like behavior and region dependently high CRP level in offspring rats.
C-reactive protein (CRP) recognizes uric acid crystals and recruits proteases C1 and MASP1.
A label-free fiber optic SPR biosensor for specific detection of C-reactive protein.
Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures.