验证数据展示
产品信息
66067-1-PBS targets Caveolin-1 in WB, IHC, IF/ICC, IF-P, ELISA applications and shows reactivity with human, mouse, rat, pig samples.
经测试应用 | WB, IHC, IF/ICC, IF-P, ELISA Application Description |
经测试反应性 | human, mouse, rat, pig |
免疫原 | Caveolin-1 fusion protein Ag8049 种属同源性预测 |
宿主/亚型 | Mouse / IgG1 |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | caveolin 1, caveolae protein, 22kDa |
别名 | Caveolin 1, CAV1, CGL3, CAV, BSCL3 |
计算分子量 | 22 kDa |
观测分子量 | 20-25 kDa |
GenBank蛋白编号 | BC006432 |
基因名称 | CAV1 |
Gene ID (NCBI) | 857 |
RRID | AB_11043343 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | Q03135 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Caveolin-1 (CAV1), a multifunctional protein, is the main constituent molecule of caveolae and represents a scaffolding molecule for several signaling molecules including epidermal growth factor receptor (PMID: 19641024). Several studies have implicated that a reduced expression of CAV1 was found in cancers including head and neck carcinoma (PMID: 19002186). However, other studies recognize CAV1 as a tumor promoter because CAV1 is overexpressed in various kinds of cancers, especially in oral cancer (PMID: 20558341). Recent study also show that CAV1 is involved in gastric Cancer (PMID: 25339030).