• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • WB analysis of human liver using 18966-1-AP

    WB analysis of human liver using 18966-1-AP

    human liver tissue were subjected to SDS PAGE followed by western blot with 18966-1-AP (KIR2DL3 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

KIR2DL3 Polyclonal antibody

KIR2DL3 Polyclonal Antibody for WB, ELISA
Cat No. 18966-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, ELISA

别名

CD158b, CD158B2, GL183, KIR 023GB, KIR K7b, KIR K7c, KIR2DL3, KIRCL23, MHC class I NK cell receptor, NKAT, NKAT 2, NKAT2, NKAT2A, NKAT2B, p58, p58 NK receptor CL 6

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -

点击咨询售前客服

点击咨询售后客服

经过测试的应用

Positive WB detected inhuman liver tissue

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:500-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

18966-1-AP targets KIR2DL3 in WB, ELISA applications and shows reactivity with human samples.

经测试应用 WB, ELISA Application Description
经测试反应性 human
免疫原 KIR2DL3 fusion protein Ag5163 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
别名 CD158b, CD158B2, GL183, KIR 023GB, KIR K7b, KIR K7c, KIR2DL3, KIRCL23, MHC class I NK cell receptor, NKAT, NKAT 2, NKAT2, NKAT2A, NKAT2B, p58, p58 NK receptor CL 6
计算分子量 341 aa, 38 kDa
观测分子量 58 kDa
GenBank蛋白编号BC032422
基因名称 KIR2DL3
Gene ID (NCBI) 3804
RRIDAB_2130398
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDP43628
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Killer cell immunoglobulin-like receptors (KIRs) are a diverse family of inhibitory and activating receptors expressed on NK cells and a subset of T cells (PMID: 11861603). These polymorphic receptors interact with specific motifs on HLA class I molecules, modulate NK cytolytic activity and are encoded by genes located on chromosome 19q13.4 (PMID: 17069649). KIR2DL3, also known as CD158B2 or NKAT2, is an inhibitory receptor that is specific for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7) (PMID: 10196125). It is a 341-amino acid transmembrane glycoprotein consisting of an extracellular region containing two C2-type Ig-like domains, a 19-amino acid hydrophobic transmembrane region, and a long cytoplasmic tail with two immunoreceptor tyrosine-based inhibitory motifs (ITIMs). KIR2DL3 inhibits the cytolytic activity of NK cells thus preventing cell lysis (PMID: 7724594).

实验方案

Product Specific Protocols
WB protocol for KIR2DL3 antibody 18966-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols