验证数据展示
发表文章中的应用
WB | See 4 publications below |
产品信息
14385-1-AP targets ASK1 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
经测试应用 | ELISA Application Description |
文献引用应用 | WB |
经测试反应性 | human, mouse, rat |
文献引用反应性 | human, rat, monkey |
免疫原 | ASK1 fusion protein Ag5818 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Polyclonal |
产品类型 | Antibody |
全称 | mitogen-activated protein kinase kinase kinase 5 |
别名 | ASK 1, ASK1, MAP3K5, MAPK/ERK kinase kinase 5, MAPKKK5, MEK kinase 5, MEKK 5, MEKK5 |
计算分子量 | 155 kDa |
GenBank蛋白编号 | BC054503 |
基因名称 | ASK1 |
Gene ID (NCBI) | 4217 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Antigen affinity purification |
UNIPROT ID | Q99683 |
储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
ASK1(Apoptosis signal-regulating kinase 1) is also named as MAP3K5, MAPKKK5, MEKK5 and belongs to the MAP kinase kinase kinase subfamily. It is an evolutionarily conserved mitogen activated protein 3-kinase that activates both Jnk and p38 mitogen-activated protein kinases. ASK1 is activated in response to various cytotoxic stresses including TNF, Fas and reactive oxygen species (ROS) such as H2O2, and activates c-Jun NH 2-terminal kinase (JNK) and p38.
发表文章
Species | Application | Title |
---|---|---|
J Mol Cell Cardiol Enhanced MiR-711 transcription by PPARγ induces endoplasmic reticulum stress-mediated apoptosis targeting calnexin in rat cardiomyocytes after myocardial infarction. | ||
Cell Microbiol \Non-haemolytic enterotoxin (Nhe) of Bacillus cereus induces apoptosis in Vero cells. | ||
Life Sci Thioredoxin-1 phosphorylated at T100 is needed for its anti-apoptotic activity in HepG2 cancer cells. | ||
J Agric Food Chem Ginsenoside F4 Alleviates Skeletal Muscle Insulin Resistance by Regulating PTP1B in Type II Diabetes Mellitus |