验证数据展示
产品信息
66404-1-PBS targets Mesothelin in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.
Tested Applications | WB, IHC, Indirect ELISA Application Description |
Tested Reactivity | human |
Immunogen | Mesothelin fusion protein Ag23606 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | mesothelin |
Synonyms | MSLN, MPF Mesothelin, cleaved form, MPF, Mesothelin, cleaved form, Megakaryocyte-potentiating factor |
Calculated Molecular Weight | 69 kDa |
Observed Molecular Weight | 69 kDa, 40 kDa |
GenBank Accession Number | BC003512 |
Gene Symbol | MSLN |
Gene ID (NCBI) | 10232 |
RRID | AB_2881778 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
UNIPROT ID | Q13421 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Mesothelin (MSLN) is a 40kDa GPI-anchored surface glycoprotein that is expressed on pleural and peritoneal mesothelial cells, but not in other non-neoplastic tissues. The mesothelin gene encodes a 69-71kDa precursor protein that is processed to a 40kDa membrane-bound protein termed mesothelin and a 31kDa shed fragment called megakaryocyte-potentiating factor (MPF) that is released from the cell. Mesothelin is a tumor differentiation antigen present at low levels on a restricted set of normal adult tissues (e.g. mesothelium), and is expressed at high levels in mesotheliomas, as well as ovarian, pancreatic, and lung cancers. Mesothelin may be a new target for immunotherapy (PMID: 20922056, 18691948, 15217923).