验证数据展示
产品信息
66878-1-PBS targets Nurr1/NR4A2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.
Tested Applications | WB, IHC, Indirect ELISA Application Description |
Tested Reactivity | human, mouse |
Immunogen | Nurr1/NR4A2 fusion protein Ag1418 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | nuclear receptor subfamily 4, group A, member 2 |
Synonyms | NURR1, NR4A2, NOT, Immediate-early response protein NOT, HZF 3 |
Calculated Molecular Weight | 66 kDa |
Observed Molecular Weight | 67 kDa |
GenBank Accession Number | BC009288 |
Gene Symbol | Nurr1 |
Gene ID (NCBI) | 4929 |
RRID | AB_2882211 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | P43354 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
NR4A2 belongs to the orphan nuclear receptor (NR) family referred to as NR4A family, which have been implicated in cell cycle regulation, apoptosis, inflammation, metabolism and more recently in carcinogenesis [PMID:22583411]. NR4A2 also has a role in the expression of several proteins that are necessary for the synthesis and regulation of DA, such as tyrosine hidroxilase, DA transporter, vesicular monoamine transporter 2, and cRET [PMID:22294735]. Act as a transcriptional regulator, NR4A2 is essential for the differentiation and maintenance of meso-diencephalic mdDA neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons [PMID: 17184956].