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验证数据展示

  • WB analysis using 66878-1-Ig (same clone as 66878-1-PBS)

    WB analysis using 66878-1-Ig (same clone as 66878-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 66878-1-Ig (Nurr1/NR4A2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66878-1-PBS in a different storage buffer formulation.

  • WB analysis using 66878-1-Ig (same clone as 66878-1-PBS)

    WB analysis using 66878-1-Ig (same clone as 66878-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 66878-1-Ig (Nurr1/NR4A2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with HRP-conjugated Beta Actin Monoclonal antibody (HRP-66009) as loading control. This data was developed using the same antibody clone with 66878-1-PBS in a different storage buffer formulation.

  • IHC staining of human prostate cancer using 66878-1-Ig (same clone as 66878-1-PBS)

    IHC staining of human prostate cancer using 66878-1-Ig (same clone as 66878-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue slide using 66878-1-Ig (Nurr1/NR4A2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66878-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with NR4A2 antibody included
  • IHC staining of human prostate cancer using 66878-1-Ig (same clone as 66878-1-PBS)

    IHC staining of human prostate cancer using 66878-1-Ig (same clone as 66878-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue slide using 66878-1-Ig (Nurr1/NR4A2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66878-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with NR4A2 antibody included
  • Featured Product
  • KD/KO验证

Nurr1/NR4A2 Monoclonal antibody, PBS Only

Nurr1/NR4A2 Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 66878-1-PBS

产品说明书

CloneNo. 1H5B4

宿主/亚型

Mouse / IgG1

种属反应性

human, mouse

应用

WB, IHC, Indirect ELISA

别名

NURR1, NR4A2, NOT, Immediate-early response protein NOT, HZF 3

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy NR4A2 Ready-To-Use IHC Kit. NR4A2 primary antibody included.

产品信息

66878-1-PBS targets Nurr1/NR4A2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原 Nurr1/NR4A2 fusion protein Ag1418 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 nuclear receptor subfamily 4, group A, member 2
别名 NURR1, NR4A2, NOT, Immediate-early response protein NOT, HZF 3
计算分子量 66 kDa
观测分子量 67 kDa
GenBank蛋白编号BC009288
基因名称 Nurr1
Gene ID (NCBI) 4929
RRIDAB_2882211
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP43354
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

NR4A2 belongs to the orphan nuclear receptor (NR) family referred to as NR4A family, which have been implicated in cell cycle regulation, apoptosis, inflammation, metabolism and more recently in carcinogenesis [PMID:22583411]. NR4A2 also has a role in the expression of several proteins that are necessary for the synthesis and regulation of DA, such as tyrosine hidroxilase, DA transporter, vesicular monoamine transporter 2, and cRET [PMID:22294735]. Act as a transcriptional regulator, NR4A2 is essential for the differentiation and maintenance of meso-diencephalic mdDA neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons [PMID: 17184956].