PR repeat Polyclonal antibody

PR repeat Polyclonal Antibody for ELISA
Cat No. 23979-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human and More (3)

应用

ELISA and More (4)

C9RAN, GGGCC, poly PR, poly-PR, PR repeat, PRPRPRPRP

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -


经过测试的应用

Positive ELISA detected inpeptide

推荐稀释比

应用推荐稀释比
Enzyme-linked Immunosorbent Assay (ELISA)ELISA : 1:10-1:100
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

23979-1-AP targets PR repeat in WB, IHC, IF, Dot Blot, ELISA applications and shows reactivity with human samples.

经测试应用 ELISA Application Description
文献引用应用WB, IHC, IF, Dot Blot
经测试反应性 human
文献引用反应性human, mouse, rat, drosophila
免疫原 Peptide 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 PR repeat
别名 C9RAN, GGGCC, poly PR, poly-PR, PR repeat, PRPRPRPRP
基因名称
Gene ID (NCBI)
RRIDAB_2879388
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

The C9orf72 "GGGGCC" repeat sequence codes five repeat peptide "GA repeat; GAGAGAGAGA", "GP repeat; GPGPGPGPG", "GR repeat; GRGRGRGRG", "AP repeat; APAPAPAPA" and "PR repeat; PRPRPRPRP". It was described previously that aggregated forms of poly-GA and poly-GP proteins do not enter the separation gel (PMID: 26374446).This antibody is used to detect the "PR repeat" sequence. This antibody detects the PRPRPRPRP peptide with dilution 1:4,500 in Elisa.

发表文章

SpeciesApplicationTitle
humanIHC

Nat Neurosci

RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats.

Authors - Shizuka B Yamada
ratWB, IF

Neuron

Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death.

Authors - Xinmei Wen
mouseIF

Nat Commun

Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR.

Authors - Zongbing Hao
humanWB, IHC

Acta Neuropathol

Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers.

Authors - Ian R A Mackenzie
humanWB

EMBO J

NDST3 deacetylates α-tubulin and suppresses V-ATPase assembly and lysosomal acidification.

Authors - Qing Tang
humanWB

EMBO J

The RNA exosome complex degrades expanded hexanucleotide repeat RNA in C9orf72 FTLD/ALS.

Authors - Yuya Kawabe
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