PR repeat Polyclonal antibody
PR repeat Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human and More (3)
Applications
ELISA and More (4)
Conjugate
Unconjugated
验证数据展示
经过测试的应用
| Positive ELISA detected in | peptide |
推荐稀释比
| Application | Dilution |
|---|---|
| Enzyme-linked Immunosorbent Assay (ELISA) | ELISA : 1:10-1:100 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
23979-1-AP targets PR repeat in WB, IHC, IF, Dot Blot, ELISA applications and shows reactivity with human samples.
| Tested Applications | ELISA Application Description |
| Cited Applications | WB, IHC, IF, Dot Blot |
| Tested Reactivity | human |
| Cited Reactivity | human, mouse, rat, drosophila |
| Immunogen | Peptide 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Full Name | PR repeat |
| Synonyms | C9RAN, GGGCC, poly PR, poly-PR, PR repeat, PRPRPRPRP |
| Gene Symbol | |
| Gene ID (NCBI) | |
| RRID | AB_2879388 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
The C9orf72 "GGGGCC" repeat sequence codes five repeat peptide "GA repeat; GAGAGAGAGA", "GP repeat; GPGPGPGPG", "GR repeat; GRGRGRGRG", "AP repeat; APAPAPAPA" and "PR repeat; PRPRPRPRP". It was described previously that aggregated forms of poly-GA and poly-GP proteins do not enter the separation gel (PMID: 26374446).This antibody is used to detect the "PR repeat" sequence. This antibody detects the PRPRPRPRP peptide with dilution 1:4,500 in Elisa.
发表文章
| Species | Application | Title |
|---|---|---|
Nat Neurosci RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats. | ||
Neuron Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death. | ||
Nat Commun Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR. | ||
Acta Neuropathol Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers. | ||
EMBO J NDST3 deacetylates α-tubulin and suppresses V-ATPase assembly and lysosomal acidification. | ||
EMBO J The RNA exosome complex degrades expanded hexanucleotide repeat RNA in C9orf72 FTLD/ALS. |
