• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • IF Staining of rat brain using 67345-1-Ig (same clone as 67345-1-PBS)

    IF Staining of rat brain using 67345-1-Ig (same clone as 67345-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed rat brain tissue using 67345-1-Ig (TDP-43 (C-terminal) antibody) at dilution of 1:500 and CoraLite488-Conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 67345-1-PBS in a different storage buffer formulation.

  • WB analysis of HeLa using 67345-1-Ig (same clone as 67345-1-PBS)

    WB analysis of HeLa using 67345-1-Ig (same clone as 67345-1-PBS)

    WB result of TDP-43 (C-terminal) antibody (67345-1-Ig; 1:30000; incubated at room temperature for 1.5 hours) with sh-Control and sh-TDP-43 (C-terminal) transfected HeLa cells. This data was developed using the same antibody clone with 67345-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 67345-1-Ig (same clone as 67345-1-PBS)

    IHC staining of mouse brain using 67345-1-Ig (same clone as 67345-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 67345-1-Ig (TDP-43 (C-terminal) antibody) at dilution of 1:5000 (under 4x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67345-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with TDP-43 antibody included
  • WB analysis using 67345-1-Ig (same clone as 67345-1-PBS)

    WB analysis using 67345-1-Ig (same clone as 67345-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67345-1-Ig (TDP-43 (C-terminal) antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67345-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

TDP-43 (C-terminal) Monoclonal antibody, PBS Only

TDP-43 (C-terminal) Monoclonal Antibody for WB, IHC, IF-P, ELISA
Cat No. 67345-1-PBS

产品说明书

CloneNo. 1G5F6

宿主/亚型

Mouse / IgG2a

种属反应性

Human, mouse, rat

应用

WB, IHC, IF-P, ELISA

别名

ALS10, TAR DNA binding protein, TAR DNA binding protein 43, TARDBP, TDP 43, TDP43, tdp-43, TDP-43 (C-terminal)

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

点击咨询售前客服

点击咨询售后客服

Planning an IHC experiment? We recommend our IHCeasy TDP-43 Ready-To-Use IHC Kit. TDP-43 primary antibody included.

产品信息

67345-1-PBS targets TDP-43 (C-terminal) in WB, IHC, IF-P, ELISA applications and shows reactivity with Human, mouse, rat samples.

经测试应用 WB, IHC, IF-P, ELISA Application Description
经测试反应性 Human, mouse, rat
免疫原 Peptide 种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 TAR DNA binding protein
别名 ALS10, TAR DNA binding protein, TAR DNA binding protein 43, TARDBP, TDP 43, TDP43, tdp-43, TDP-43 (C-terminal)
计算分子量 43 kDa
观测分子量 43-45 kDa
GenBank蛋白编号NM_007375
基因名称 TDP-43
Gene ID (NCBI) 23435
RRIDAB_2882603
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ13148
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Transactivation response (TAR), DNA-binding protein of 43 kDa (also known as TARDBP or TDP-43), was first isolated as a transcriptional inactivator binding to the TAR DNA element of the HIV-1 virus. Neumann et al. (2006) found that a hyperphosphorylated, ubiquitinated, and cleaved form of TARDBP, known as pathologic TDP-43, is the major component of the tau-negative and ubiquitin-positive inclusions that characterize amyotrophic lateral sclerosis (ALS) and the most common pathological subtype of frontotemporal lobar degeneration (FTLD-U). 67345-1-Ig is a mouse monoclonal antibody raised against the C-terminal region of human TDP-43.