验证数据展示
产品信息
66350-1-PBS targets TLR4 in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat, pig samples.
Tested Applications | WB, IHC, ELISA Application Description |
Tested Reactivity | human, mouse, rat, pig |
Immunogen | TLR4 fusion protein Ag13857 种属同源性预测 |
Host / Isotype | Mouse / IgG2b |
Class | Monoclonal |
Type | Antibody |
Full Name | toll-like receptor 4 |
Synonyms | toll like receptor 4, TOLL, hToll, CD284, ARMD10 |
Calculated Molecular Weight | 839 aa, 96 kDa |
Observed Molecular Weight | 100-110 kDa |
GenBank Accession Number | BC117422 |
Gene Symbol | TLR4 |
Gene ID (NCBI) | 7099 |
RRID | AB_2881730 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | O00206 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
TLR4, also named CD284, belongs to the Toll-like receptor family. TLR4 interacts with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). TLR4 acts via MYD88, TIRAP and TRAF6, leading to NF-kB activation, cytokine secretion, and the inflammatory response. Three alternatively spliced transcript variants that encode different protein isoforms have been described.