验证数据展示
发表文章中的应用
| WB | See 5 publications below |
| IHC | See 1 publications below |
产品信息
11160-1-AP targets WNT2 in WB, IHC, ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB, IHC |
| 经测试反应性 | human, mouse |
| 文献引用反应性 | human, mouse |
| 免疫原 | WNT2 fusion protein Ag1641 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | wingless-type MMTV integration site family member 2 |
| 别名 | Int 1 like protein 1, Int 1 related protein, INT1L1, IRP, Protein Wnt 2, WNT2 |
| 计算分子量 | 40 kDa |
| GenBank蛋白编号 | BC029854 |
| 基因名称 | WNT2 |
| Gene ID (NCBI) | 7472 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P09544 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Wnt2 is a secreted glycoprotein that is one of the canonical Wnt ligands. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Wnt2 is known to directly regulate β-catenin activity, the key player in proliferation and inflammation. Recently, studies have demonstrated that Wnt2 is overexpressed in various human cancers, including esophageal, gastric, colorectal, breast, lung, cervical, and malignant glioma.
发表文章
| Species | Application | Title |
|---|---|---|
J Biol Chem HBP1-mediated regulation of p21 through Mdm2/p53 and TCF4/EZH2 pathways and its impact on cell senescence and tumorigenesis. | ||
PLoS One Plasma miR-199a-5p is increased in neutrophilic phenotype asthma patients and negatively correlated with pulmonary function. | ||
Int J Oncol CD82 inhibits canonical Wnt signalling by controlling the cellular distribution of β-catenin in carcinoma cells. | ||
Oncol Rep RNA-binding motif protein 5 negatively regulates the activity of Wnt/β-catenin signaling in cigarette smoke-induced alveolar epithelial injury. | ||
Neurol Res Wnt signaling pathway is involved in the pathogenesis of amyotrophic lateral sclerosis in adult transgenic mice. |