Validation Data Gallery
Technical Specifications
| GeneID | 3456 |
| Species | Human |
| Expression | HEK293 |
| Activity | 0.015-0.08 ng/mL |
| Specific Activity | minimally 1.00 x 109 IU/mg |
| Purity | >95% |
| Endotoxin | <1 EU/μg |
| Accession Number | P01574 |
| Molecular Mass | 21 to 24 kDa reduced, 20 to 23 and 38 to 42 non-reduced, glycosylated |
| Formulation | Sodium Acetate pH 4.8 + 150mM NaCl + CHAPS, See Certificate of Analysis for details |
| Species Reactivity | human |
Stability and Reconstitution
| Stability and Storage | Product Form | Temperature Conditions | Storage Time (From Date of Receipt) |
|---|---|---|---|
| Lyophilized | -20°C to -80°C | Until Expiry Date | |
| Lyophilized | Room Temperature | 2 weeks | |
| Reconstituted as per CofA | -20°C to -80°C | 6 months | |
| Reconstituted as per CofA | 4°C | 1 week | |
| Avoid repeated freeze-thaw cycles. | |||
| Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in sterile water. Gently swirl or tap vial to mix. |
Background
IFN beta is a member of type I family of interferons. It binds to the IFNα/β receptor (IFNAR), activating the Jak/ STAT pathway. Activation of this signaling pathway results in upregulating genes that inhibit viral infection and regulate MHC class I antigens. It is primarily produced by fibroblasts and monocytes. In addition to inhibiting viral infection, IFN beta is also involved in regulating and activating immune response against bacteria, parasite and tumor cells. Multiple sclerosis is characterized by a deficiency of IFN beta 1. An injectable form of IFN beta 1 is used for MS treatment (PMID: 22222875; 29258190; 8602746; 8469318).
Synonyms
Fibroblast interferon, IFB, IFF, IFN beta, IFNB, IFNB1, Interferon beta, interferon, beta 1, fibroblast
Publications
| Species | Title |
|---|---|
Immunity Maternal natural killer cells drive neuroimmune disorders in offspring through aberrant secretion of extracellular granzyme B | |
Nucleic Acids Res Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8. | |
Adv Sci (Weinh) RNF138-Mediated Ubiquitination and Degradation of NS5 Restricts Tick-Borne Encephalitis Virus Infection. | |
Oncogene Reciprocal regulation between ferroptosis and STING-type I interferon pathway suppresses head and neck squamous cell carcinoma growth through dendritic cell maturation | |
Int J Biol Macromol Porcine deltacoronavirus NS7a antagonizes JAK/STAT pathway by inhibiting the interferon-stimulated gene factor 3 (ISGF3) formation |
