- HEK293 expressed
- Endotoxin-free
- Animal-component free
HumanKine® recombinant human TGF beta 2 protein
Activity
0.018-0.18 ng/mL EC50
Specific Activity
3.52 x 107 IU/mg
Species Reactivity
human,mouse
Purity
>95%
Cat No : HZ-1092
Synonyms
BSC 1 cell growth inhibitor, Cetermin, G TSF, Polyergin, TGF beta 2, TGF beta2, TGFB2
Validation Data Gallery
Technical Specifications
GeneID | 7042 |
Species | Human |
Expression | HEK293 |
Activity | 0.018-0.18 ng/mL EC50 |
Specific Activity | 3.52 x 107 IU/mg |
Purity | >95% |
Endotoxin | <1 EU/μg |
Accession Number | P27090 |
Molecular Mass | 25 kDa, homodimer, non-glycosylated |
Formulation | 50 mM NaOAc pH 4.5, See Certificate of Analysis for details |
Species Reactivity | human,mouse |
Stability and Reconstitution
Stability and Storage | Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products. |
Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 20% ethanol + 50 mM NaOAc + 75 mM HOAc. |
Background
Transforming growth factor beta-2 (TGFB2) belongs to the TGF-beta family. TGFB2 is a secreted protein known as a cytokine that plays a vital role during embryonic development (PMID 19289080). TGFB2 regulates cell proliferation, differentiation, adhesion, migration by transducing the signal through transmembrane receptors type I and type II (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins (PMID 18313409). Disruption of the TGFB/SMAD pathway has been implicated in many cancers types. TGFB2 has suppressive effects on interleukin-2 dependent T-cell growth (PMID 12064833). The TGFβ2 protein plays a role in the blood vessels formation, the regulation of muscle tissue and body fat development. TGFβ-2 is especially abundant in tissues related to the skeleton, where it helps regulate bone growth and form the extracellular matrix in the spaces between cells.
Synonyms
BSC 1 cell growth inhibitor, Cetermin, G TSF, Polyergin, TGF beta 2, TGF beta2, TGFB2
Publications
Species | Title |
---|---|
J Cell Mol Med FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity. | |
Biol Reprod Constitutive activation of transforming growth factor Beta receptor 1 in the mouse uterus impairs uterine morphology and function. | |
Invest Ophthalmol Vis Sci Aldose Reductase Mediates Transforming Growth Factor β2 (TGF-β2)-Induced Migration and Epithelial-To-Mesenchymal Transition of Lens-Derived Epithelial Cells. | |
Front Oncol Association of the TGFβ gene family with microenvironmental features of gastric cancer and prediction of response to immunotherapy |