NeutraKine® IL-12/IL-23 p40 Mouse McAb

NeutraKine® IL-12/IL-23 p40 Monoclonal Antibody for Neutralization, ELISA
Cat No. 69006-1-Ig

产品说明书

CloneNo. 2A9H6

宿主/亚型

Mouse / IgG1

种属反应性

human

应用

Neutralization, ELISA

IL-12/IL-23 p40, IL12B, IL 12B, IL 12 subunit p40, IL 12 P40

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -


Neutralization

产品信息

69006-1-Ig targets NeutraKine® IL-12/IL-23 p40 in Neutralization, ELISA applications and shows reactivity with human samples.

经测试应用 Neutralization, ELISA Application Description
经测试反应性 human
免疫原 human Humankine IL-12/IL-23 p40 protein HZ-1254 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
别名 IL-12/IL-23 p40, IL12B, IL 12B, IL 12 subunit p40, IL 12 P40
计算分子量 328 aa, 37 kDa
GenBank蛋白编号BC067498
基因名称 IL12B
Gene ID (NCBI) 51561,3593
RRIDAB_2882924
偶联类型 Unconjugated
形式 Lyophilized Powder
纯化方式Protein A purification
UNIPROT IDP29460
储存缓冲液 Sterile PBS , pH 7.4
内毒素<0.1 EU/μg
复溶This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
稳定性与储存Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

背景介绍

IL-12 and IL-23 are heterodimeric cytokines that share a common p40 subunit (PMID: 11114383). IL-12 is composed of the IL-12 p40 subunit linked to the IL-12 p35 subunit, and the heterodimer signals through the IL-12 receptor (IL-12R), which comprises the IL-12Rβ1 and IL-12Rβ2 subunits. IL-23 is composed of the IL-23 p19 subunit and the IL-12 p40 (IL-12/23p40) subunit, which signals through IL-23R and IL-12Rβ1 (PMID: 11114383; 26121196 ). IL-12/IL-23 p40 also exists as a monomer and as a homodimer which can act as a potent IL-12 antagonist (PMID: 8958912; 18783467). IL-12/IL-23 p40 is produced by antigen-presenting cells, such as dendritic cells (DCs), monocytes, macrophages, neutrophils and, to a lesser extent, B cells (PMID: 20476918).

This antibody can be used to neutralize the bioactivity of IL-12/IL-23 p40.

Loading...