验证数据展示
| Neutralization | OCI-AML5 cells |
产品信息
69033-1-Ig targets NeutraKine®M-CSF in ELISA, Neutralization applications and shows reactivity with Human samples.
| 经测试应用 | ELISA, Neutralization Application Description |
| 经测试反应性 | Human |
| 免疫原 | human HumankineM-CSF protein HZ-1192 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 亲和力 | KD=8.48 x 10-9M KOff=4.75 x 10-4M KOn=5.60 x 104M |
| 全称 | colony stimulating factor 1 (macrophage) |
| 别名 | CSF 1, CSF1, Lanimostim, M CSF, MCSF, M-CSF, NeutraKine®M-CSF |
| 基因名称 | M-CSF |
| Gene ID (NCBI) | 1435 |
| RRID | AB_3085334 |
| 偶联类型 | Unconjugated |
| 形式 | Lyophilized Powder |
| 纯化方式 | Protein G purification |
| 储存缓冲液 | Sterile PBS , pH 7.4 |
| 内毒素 | <0.1 EU/μg |
| 复溶 | This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use. |
| 稳定性与储存 | Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products. |
背景介绍
M-CSF plays an essential role in the regulation of survival, proliferation, and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes. M-CSF promotes the release of proinflammatory chemokines and thereby plays an important role in innate immunity and in inflammatory processes. It also plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. On the cellular level, M-CSF promotes reorganization of the actin cytoskeleton, regulates the formation of membrane ruffles, cell adhesion, and cell migration, and plays a role in lipoprotein clearance.
This antibody is used to neutralize the bioactivity of M-CSF.
