验证数据展示
产品信息
65103-1-PBS targets CD40 as part of a matched antibody pair:
MP50064-1: 66965-2-PBS capture and 65103-1-PBS detection (validated in Sandwich ELISA)
Unconjugated mouse monoclonal antibody pair in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation.
This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.
经测试应用 | FC, Sandwich ELISA, Indirect ELISA, Sample test Application Description |
经测试反应性 | human |
免疫原 | N/A 种属同源性预测 |
宿主/亚型 | Mouse / IgG1, kappa |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | CD40 molecule, TNF receptor superfamily member 5 |
别名 | p50, G28.5, CD40L receptor, Bp50, B-cell surface antigen CD40 |
计算分子量 | 277 aa, 31 kDa |
GenBank蛋白编号 | BC012419 |
基因名称 | CD40 |
Gene ID (NCBI) | 958 |
ENSEMBL Gene ID | ENSG00000101017 |
RRID | AB_2881471 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Affinity purification |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
CD40, also named as TNFRSF5 and Bp50, is a type I transmembrane protein that belongs to the tumor necrosis factor-R (TNF-R) family (PMID: 10647992). CD40 is expressed on B cells, dendritic cells (DCs), monocytes, platelets, and macrophages as well as by non-hematopoietic cells such as myofibroblasts, fibroblasts, epithelial, and endothelial cells (PMID: 19426221). It is a receptor for TNFSF5/CD40LG. CD40L/CD40 interactions are essential for immunoglobulin (Ig) isotype switching, germinal center formation and the development of B cell memory (PMID: 7516405; 11675497).