验证数据展示
产品信息
60084-1-PBS targets DGCR8 in WB, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat, pig samples.
Tested Applications | WB, IP, Indirect ELISA Application Description |
Tested Reactivity | human, mouse, rat, pig |
Immunogen | DGCR8 fusion protein Ag4871 种属同源性预测 |
Host / Isotype | Mouse / IgG2a |
Class | Monoclonal |
Type | Antibody |
Full Name | DiGeorge syndrome critical region gene 8 |
Synonyms | C22orf12, DGCR8, DGCRK6, Gy1 |
Calculated Molecular Weight | 773 aa, 86 kDa |
Observed Molecular Weight | 120 kDa |
GenBank Accession Number | BC009323 |
Gene Symbol | DGCR8 |
Gene ID (NCBI) | 54487 |
RRID | AB_2090985 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | Q8WYQ5 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
DGCR8 is a RNA-binding protein that assists the Rnase III enzyme Drosha in the processing of microRNAs (miRNAs), which regulate the expression of a large number of protein-coding genes[PMID: 22580560]. DGCR8, which contains two double-stranded RNA (dsRNA)-binding domains, may be an essential component of the primary miRNAs processing complex, along with Drosha, promoting the processing of primary microRNA to precursor microRNA. It is ubiquitous expressed in human and mouse tissues, and is deleted in DiGeorge syndrome[22323604]. The calculated molecular weight of DGCR8 is 82-86 kDa, but the post-modified DGCR8 is about 120 kDa.