CoraLite®555-conjugated FUS/TLS Polyclonal antibody
FUS/TLS Polyclonal Antibody for FC (Intra)
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse, rat
Applications
FC (Intra)
Conjugate
CoraLite®555 Fluorescent Dye
验证数据展示
For IHC detection, 60160-1-Ig (mAB) is better.
Planning an IHC experiment? We recommend our IHCeasy FUS/TLS Ready-To-Use IHC Kit. FUS/TLS primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 11570-1-AP
产品信息
CL555-11570 targets FUS/TLS in FC (Intra) applications and shows reactivity with human, mouse, rat samples.
Tested Applications | FC (Intra) Application Description |
Tested Reactivity | human, mouse, rat |
Immunogen | FUS/TLS fusion protein Ag2150 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Full Name | fusion (involved in t(12;16) in malignant liposarcoma) |
Synonyms | 75 kDa DNA pairing protein, FUS, FUS1, FUS-CHOP, hnRNP P2, Oncogene FUS, Oncogene TLS, POMp75, RNA binding protein FUS, TLS, TLS/CHOP |
Calculated Molecular Weight | 75 kDa |
Observed Molecular Weight | 68-75 kDa |
GenBank Accession Number | BC026062 |
Gene Symbol | FUS |
Gene ID (NCBI) | 2521 |
RRID | AB_2919602 |
Conjugate | CoraLite®555 Fluorescent Dye |
Excitation/Emission Maxima Wavelengths | 557 nm / 570 nm |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | P35637 |
Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
FUS (also named TLS and POMp75) belongs to the RRM TET family. FUS may play a role in the maintenance of genomic integrity; it binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. FUS is also an RNA-binding protein, and its links to neurodegenerative disease proffer the intriguing possibility that altered RNA metabolism or RNA processing may underlie or contribute to neuron degeneration[PMID: 22640227]. FUS may be a cause of angiomatoid fibrous histiocytoma (AFH) and is implicated in certain forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementias (FTDs) such as frontotemporal lobar dementia with ubiquitin inclusions (FTLD-U)[PMID: 22640227]. This antibody is a rabbit polyclonal antibody raised against an internal region of human FUS.
实验方案
Product Specific Protocols | |
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IF protocol for CL555 FUS/TLS antibody CL555-11570 | Download protocol |
FC protocol for CL555 FUS/TLS antibody CL555-11570 | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |