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  • Featured Product
  • KD/KO Validated

IFITM2-specific Monoclonal antibody, PBS Only

IFITM2-specific Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

3D5F7

Cat No : 66137-1-PBS

Print datasheet

Synonyms

DSPA2c, IFITM2, IFITM2-specific

验证数据展示

  • WB analysis of HepG2 using 66137-1-Ig (same clone as 66137-1-PBS)

    WB analysis of HepG2 using 66137-1-Ig (same clone as 66137-1-PBS)

    HepG2 cells were subjected to SDS PAGE followed by western blot with 66137-1-Ig (IFITM2-specific antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66137-1-PBS in a different storage buffer formulation.

  • WB analysis of recombinant protein using 66137-1-Ig (same clone as 66137-1-PBS)

    WB analysis of recombinant protein using 66137-1-Ig (same clone as 66137-1-PBS)

    IFITM1 (Lane 1), IFITM2 (Lane 2) and IFITM3 (Lane 3) fusion proteins (20ng/lane) were subjected to SDS-PAGE followed by western blot with IFITM2 monoclonal antibody (66137-1-Ig) at dilution of 1:10,000. This data was developed using the same antibody clone with 66137-1-PBS in a different storage buffer formulation.

产品信息

66137-1-PBS targets IFITM2-specific in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human
Immunogen Recombinant protein 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name interferon induced transmembrane protein 2 (1-8D)
Synonyms DSPA2c, IFITM2, IFITM2-specific
Observed Molecular Weight 15 kDa
GenBank Accession NumberNM_006435
Gene Symbol IFITM2
Gene ID (NCBI) 10581
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDQ01629
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

IFITM2, also named as 1-8D, belongs to the CD225 family. It is an IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. IFITM2 induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. It is overexpressed in colon carcinoma. IFITM2 is a novel pro-apoptotic gene that will provide new insights into the regulated cellular pathways to death.(PMID:19544527) This antibody is specific to IFTIM2.