验证数据展示
经过测试的应用
Positive IF-P detected in | rat brain tissue |
推荐稀释比
应用 | 推荐稀释比 |
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Immunofluorescence (IF)-P | IF-P : 1:150-1:600 |
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
产品信息
CL594-67345 targets TDP-43 (C-terminal) in IF-P applications and shows reactivity with Human, mouse, rat samples.
经测试应用 | IF-P Application Description |
经测试反应性 | Human, mouse, rat |
免疫原 | Peptide 种属同源性预测 |
宿主/亚型 | Mouse / IgG2a |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | TAR DNA binding protein |
别名 | ALS10, TAR DNA binding protein, TAR DNA binding protein 43, TARDBP, TDP 43, TDP43 |
计算分子量 | 43 kDa |
观测分子量 | 43-45 kDa |
GenBank蛋白编号 | NM_007375 |
基因名称 | TDP-43 |
Gene ID (NCBI) | 23435 |
RRID | AB_2889841 |
偶联类型 | CoraLite®594 Fluorescent Dye |
最大激发/发射波长 | 588 nm / 604 nm |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | Q13148 |
储存缓冲液 | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA , pH 7.3 |
储存条件 | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Transactivation response (TAR), DNA-binding protein of 43 kDa (also known as TARDBP or TDP-43), was first isolated as a transcriptional inactivator binding to the TAR DNA element of the HIV-1 virus. Neumann et al. (2006) found that a hyperphosphorylated, ubiquitinated, and cleaved form of TARDBP, known as pathologic TDP-43, is the major component of the tau-negative and ubiquitin-positive inclusions that characterize amyotrophic lateral sclerosis (ALS) and the most common pathological subtype of frontotemporal lobar degeneration (FTLD-U). 67345-1-Ig is a mouse monoclonal antibody raised against the C-terminal region of human TDP-43.
实验方案
Product Specific Protocols | |
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IF protocol for CL594 TDP-43 (C-terminal) antibody CL594-67345 | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |