验证数据展示
产品信息
66345-1-PBS targets VDAC1/Porin in WB, IF-P, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Applications | WB, IF-P, FC (Intra), Indirect ELISA Application Description |
Tested Reactivity | human, mouse, rat |
Immunogen | Peptide 种属同源性预测 |
Host / Isotype | Mouse / IgG3 |
Class | Monoclonal |
Type | Antibody |
Full Name | voltage-dependent anion channel 1 |
Synonyms | Porin, VDAC1, Porin 31HL, PORIN 31 HL, Plasmalemmal porin |
Calculated Molecular Weight | 31 kDa |
Observed Molecular Weight | 35-37 kDa |
GenBank Accession Number | NM_003374 |
Gene Symbol | Porin |
Gene ID (NCBI) | 7416 |
RRID | AB_2881725 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | P21796 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
VDAC1, also named as VDAC, porin 31HM, porin 31HL and plasmalemmal porin, belongs to the eukaryotic mitochondrial porin family. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV, to form a channel through the mitochondrial outer membrane and also the plasma membrane. Unlike other membrane transport proteins, porins are large enough to allow passive diffusion. Studies have shown that VDAC1 is subject to both phosphorylation and acetylation (PMID: 23233904). The apparent molecular weight of VDAC1 is 30-37 kDa (PMID: 14573604; 23754752; 25681439). Hypoxic conditions were found to trigger cleavage of the VDAC1 C-terminal to yield a 26-kDa truncated but active form (PMID: 22389449; 23233904).