验证数据展示
产品信息
81984-2-PBS targets Histone H3 in WB, IHC, IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
经测试应用 | WB, IHC, IF/ICC, FC (Intra), Indirect ELISA Application Description |
经测试反应性 | human, mouse, rat |
免疫原 | Histone H3 fusion protein Ag10644 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | histone cluster 2, H3a |
别名 | HIST2H3A, 241079B2, H3C13, H3C14, H3C15 |
计算分子量 | 136 aa, 15 kDa |
观测分子量 | 15-17 kDa |
GenBank蛋白编号 | BC015544 |
基因名称 | Histone H3 |
Gene ID (NCBI) | 333932 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purfication |
UNIPROT ID | Q71DI3 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Histone-H3, histone cluster 2, H3a is the core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machinery which requires DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histone-H3 is expressed during S phase; then expression strongly decreases as cell division slows down during the process of differentiation.