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CoraLite®594-conjugated LONP1 Monoclonal antibody

LONP1 Monoclonal Antibody for IF/ICC
Cat No. CL594-66043

产品说明书

CloneNo. 1C6C12

宿主/亚型

Mouse / IgG1

种属反应性

human, mouse, rat

应用

IF/ICC

Mitochondrial ATP-dependent protease Lon, LONP 1, LONP, LON, EC:3.4.21.53

缓冲液配方:  PBS and Azide
PBS and Azide
规格: 

-/ -


经过测试的应用

Positive IF/ICC detected inC6 cells
For other applications, we recommend the unconjugated version of this antibody, 66043-1-Ig

推荐稀释比

应用推荐稀释比
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL594-66043 targets LONP1 in IF/ICC applications and shows reactivity with human, mouse, rat samples.

经测试应用 IF/ICC Application Description
经测试反应性 human, mouse, rat
免疫原 LONP1 fusion protein Ag7306 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 lon peptidase 1, mitochondrial
别名 Mitochondrial ATP-dependent protease Lon, LONP 1, LONP, LON, EC:3.4.21.53
计算分子量 106 kDa
观测分子量 100 kDa
GenBank蛋白编号BC000235
基因名称 LONP1
Gene ID (NCBI) 9361
RRIDAB_2919942
偶联类型 CoraLite®594 Fluorescent Dye
最大激发/发射波长588 nm / 604 nm
形式 Liquid
纯化方式Protein G purification
UNIPROT IDP36776
储存缓冲液 PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA , pH 7.3
储存条件Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

LONP1(Lon protease homolog, mitochondrial) is also named as LONP, LONHS, HLON, LON, PRSS15, PIM1, MGC1498 and belongs to the peptidase S16 family. It seems to play a major role in the elimination of oxidatively modified proteins in the mitochondrial matrix(PMID:18021745). LONP1, also a nuclearly encoded and mitochondrially located stress-responsive protease, is involved in heme-mediated ALAS-1 turnover(PMID:21659532). It recognizes specific surface determinants or folds, initiates proteolysis at solvent-accessible sites, and generates unfolded polypeptides that are then processively degraded(PMID:15870080).

实验方案

Product Specific Protocols
IF protocol for CL594 LONP1 antibody CL594-66043Download protocol
Standard Protocols
Click here to view our Standard Protocols
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