GSK3 signaling: Pathway Poster

All the posters in the Proteintech library are available in PDF format or can be requested as a hard copy.

GSK3 Pathway Overview

GSK3 (Glycogen Synthase Kinase-3) is a signaling mediator involved in a variety of different signaling pathways including WNT, growth factors, insulin, and Hedgehog pathways.

Recent studies have shown GSK3 dysregulation to be associated with a number of diseases, including Type II diabetes, Alzheimer’s disease, inflammation, cancer, and bipolar disorder (D Wu and W Pan. 2010). It has also been suggested that inhibition of GSK has the capacity to undergo oxidative metabolism and has protective effects on neurons, counteracting ischemic neuronal death (Valerio et al., 2011).

Download the GSK3 signaling pathway poster here

Related Antibodies

References

D Wu and W Pan. (2010). GSK3: a multifaceted kinase in Wnt signaling. Trends Biochem Sci. 35 (3), p161–168.

Valerio A et al. (2011). Glycogen synthase kinase-3 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production.. J Neurochem. 116 (6), p1471-4159.