Lung Cancer

Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using MCM6 polyclonal antibody (13347-2-AP), the #1 cited antibody on the market. MCM6 plays a crucial role in lung cancer metastasis.

Introduction

Lung cancer is the second most common cancer worldwide and by far the leading cause of cancer-related deaths. There are two major forms of lung cancer. Non-small cell lung cancer (NSCLC) accounts for most cases and can be divided into several different types including adenocarcinoma, squamous cell, and large cell carcinoma. Small cell lung cancers account for about 10-15% of lung cancer cases but are more invasive and faster growing than NSCLC. While smoking remains the number one cause of lung cancer, exposure to toxic chemicals as well as inherited and acquired genetic mutations can also contribute towards developing this disease. Proteintech offers several antibodies and IHC kits to study disease progression and to identify existing and potential biomarkers for targeted therapies. Many of these products have already been validated in lung cancer tissue.

Featured Markers for Lung Cancer Research

KRAS

KRAS is an oncogenic protein that has the second highest rate of mutation in NSCLC behind p53. It is a member of the RAS family of proteins that coordinate several cellular activities including proliferation, survival, and cytoskeletal remodeling. KRAS mutations are often corelated with poor survival and response to treatment. Proteintech’s KRAS antibody is one of the most cited in the market, already featured in nearly 100 publications worldwide.

Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 12063-1-AP (KRAS antibody) at dilution of 1:800 (under 10x lens).

MET

MET is a receptor tyrosine kinase that is activated upon binding with its ligand, HGF. Ligand binding activates several downstream cellular responses including cell growth, adhesion, and motility. In lung cancer, this protein is often overexpressed or affected by gain-of-function mutations. These alterations result in dysregulated signaling and increased cancer invasiveness. Several inhibitory drugs and monoclonal antibodies have been developed to target aberrant MET activity in lung cancer.  

Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 25869-1-AP (c-Met antibody) at dilution of 1:1000 (under 10x lens).

STK11

STK11, also known as LKB1, is a protein kinase that controls the activity of members of the AMP-activated protein kinase (AMPK) family. It is normally a tumor suppressor that functions as an upstream regulator of cell polarization, apoptosis, and the DNA damage response. However, STK11 is affected by loss of function mutations in nearly 13% of lung adenocarcinomas, which result in oncogenic functions. Lung cancers carrying mutated forms of STK11 tend to have a higher propensity for metastasis and lower overall survival.

Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 10746-1-AP (STK11/LKB1 antibody) at dilution of 1:200 (under 10x lens).

Antibodies for Lung Cancer

IHC Kits for Lung Cancer 

References

Greulich, H. (2010). The Genomics of Lung Adenocarcinoma: Opportunities for Targeted Therapies. Genes & Cancer, 1(12), 1200–1210. https://doi.org/10.1177/1947601911407324

Laderian, B., Mundi, P. S., Fojo, T., & Bates, S. E. (2020). Emerging Therapeutic Implications of STK11 Mutation: Case Series. Oncologist, 25(9), 733–737. https://doi.org/10.1634/theoncologist.2019-0846

Lawrence, R. E., & Salgia, R. (2009). MET molecular mechanisms and therapies in lung cancer. Cell Adhesion & Migration, 4(1), 146–152. https://doi.org/10.4161/cam.4.1.10973

Sumbly, V., & Landry, I. (2022). Unraveling the Role of STK11/LKB1 in Non-small Cell Lung Cancer. Cureus. https://doi.org/10.7759/cureus.21078

Villalobos, P., & Wistuba, I. I. (2017). Lung Cancer Biomarkers. Hematology-Oncology Clinics of North America, 31(1), 13–29. https://doi.org/10.1016/j.hoc.2016.08.006

What Is Lung Cancer? | Types of Lung Cancer. (n.d.). https://www.cancer.org/cancer/lung-cancer/about/what-is.html

Related Content

Cancer research resources

Cancer and metastasis

Cancer and the immune system

Cancer stem cells as a key to cure cancer

Brain tumor markers

Molecular markers for liver cancer

Leukemia markers

Ovarian cancer

Kidney cancer

Support

Videos

Protocols

Pathway Posters Library

Early Career Researcher Hub